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2jnr

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==Discovery and optimization of a natural HIV-1 entry inhibitor targeting the gp41 fusion peptide==
==Discovery and optimization of a natural HIV-1 entry inhibitor targeting the gp41 fusion peptide==
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<StructureSection load='2jnr' size='340' side='right' caption='[[2jnr]], [[NMR_Ensembles_of_Models | 1 NMR models]]' scene=''>
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<StructureSection load='2jnr' size='340' side='right'caption='[[2jnr]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2jnr]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JNR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JNR FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2jnr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JNR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JNR FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jnr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jnr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jnr RCSB], [http://www.ebi.ac.uk/pdbsum/2jnr PDBsum]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<table>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jnr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jnr OCA], [https://pdbe.org/2jnr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jnr RCSB], [https://www.ebi.ac.uk/pdbsum/2jnr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jnr ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q72502_9HIV1 Q72502_9HIV1] The envelope glyprotein gp160 precursor down-modulates cell surface CD4 antigen by interacting with it in the endoplasmic reticulum and blocking its transport to the cell surface.[RuleBase:RU004292]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 2jnr" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Adermann, K.]]
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[[Category: Large Structures]]
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[[Category: Biet, T.]]
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[[Category: Synthetic construct]]
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[[Category: Chaipan, C.]]
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[[Category: Adermann K]]
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[[Category: Forssmann, W.]]
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[[Category: Biet T]]
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[[Category: Jiang, S.]]
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[[Category: Chaipan C]]
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[[Category: Jing, W.]]
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[[Category: Forssmann W]]
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[[Category: Kirchhoff, F.]]
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[[Category: Jiang S]]
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[[Category: Lu, H.]]
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[[Category: Jing W]]
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[[Category: Meyer, B.]]
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[[Category: Kirchhoff F]]
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[[Category: Munch, J.]]
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[[Category: Lu H]]
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[[Category: Peters, T.]]
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[[Category: Meyer B]]
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[[Category: Pohlmann, S.]]
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[[Category: Munch J]]
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[[Category: Schulz, A.]]
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[[Category: Peters T]]
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[[Category: Standker, L.]]
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[[Category: Pohlmann S]]
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[[Category: Wilhelm, D.]]
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[[Category: Schulz A]]
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[[Category: Peptide complex]]
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[[Category: Standker L]]
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[[Category: Viral protein]]
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[[Category: Wilhelm D]]

Current revision

Discovery and optimization of a natural HIV-1 entry inhibitor targeting the gp41 fusion peptide

PDB ID 2jnr

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