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2oyv

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[[Image:2oyv.png|left|200px]]
 
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{{STRUCTURE_2oyv| PDB=2oyv | SCENE= }}
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==Neurotensin in DPC micelles==
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<StructureSection load='2oyv' size='340' side='right'caption='[[2oyv]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2oyv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OYV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OYV FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2oyv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oyv OCA], [https://pdbe.org/2oyv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2oyv RCSB], [https://www.ebi.ac.uk/pdbsum/2oyv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2oyv ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NEUT_HUMAN NEUT_HUMAN] Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Neurotensin (NT) is a 13-residue neuropeptide that exerts multiple biological functions in the central and peripheral nervous system. Little is known about the structure of this neuropeptide, and what is known only concerns its C-terminal part. We determined here for the first time the structure of the full-length NT in membrane-mimicking environments by means of classical proton-proton distance constraints derived from solution-state NMR spectroscopy. NT was found to have a structure at both its N and C termini, whereas the central region of NT remains highly flexible. In TFE and HFIP solutions, the NT C-terminus presents an extended slightly incurved structure, whereas in DPC it has a beta turn. The N-terminal region of NT possesses great adaptability and accessibility to the microenvironment in the three media studied. Altogether, our work demonstrates a structure of NT fully compatible with its NTR-bound state.
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===Neurotensin in DPC micelles===
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NMR solution structure of neurotensin in membrane-mimetic environments: molecular basis for neurotensin receptor recognition.,Coutant J, Curmi PA, Toma F, Monti JP Biochemistry. 2007 May 15;46(19):5656-63. Epub 2007 Apr 19. PMID:17441729<ref>PMID:17441729</ref>
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{{ABSTRACT_PUBMED_17441729}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 2oyv" style="background-color:#fffaf0;"></div>
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[[2oyv]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OYV OCA].
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:017441729</ref><references group="xtra"/>
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</StructureSection>
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[[Category: Coutant, J.]]
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[[Category: Homo sapiens]]
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[[Category: Curmi, P A.]]
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[[Category: Large Structures]]
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[[Category: Monti, J P.]]
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[[Category: Coutant J]]
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[[Category: Neuropeptide]]
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[[Category: Curmi PA]]
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[[Category: Type i turn]]
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[[Category: Monti JP]]

Current revision

Neurotensin in DPC micelles

PDB ID 2oyv

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