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2v52

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==Structure of MAL-RPEL2 complexed to G-actin==
==Structure of MAL-RPEL2 complexed to G-actin==
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<StructureSection load='2v52' size='340' side='right' caption='[[2v52]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
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<StructureSection load='2v52' size='340' side='right'caption='[[2v52]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2v52]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V52 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2V52 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2v52]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V52 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2V52 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=LAB:LATRUNCULIN+B'>LAB</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.45&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1lcu|1lcu]], [[2a42|2a42]], [[2aso|2aso]], [[1ijj|1ijj]], [[1wua|1wua]], [[1o18|1o18]], [[1m8q|1m8q]], [[1o1a|1o1a]], [[1rfq|1rfq]], [[1uy5|1uy5]], [[1ma9|1ma9]], [[2d1k|2d1k]], [[1rdw|1rdw]], [[1o1b|1o1b]], [[1o1d|1o1d]], [[2a40|2a40]], [[2a5x|2a5x]], [[1qz5|1qz5]], [[1nwk|1nwk]], [[1j6z|1j6z]], [[1sqk|1sqk]], [[1atn|1atn]], [[1s22|1s22]], [[1t44|1t44]], [[2ff3|2ff3]], [[1eqy|1eqy]], [[1mvw|1mvw]], [[2ff6|2ff6]], [[2fxu|2fxu]], [[1o1f|1o1f]], [[1kxp|1kxp]], [[2asp|2asp]], [[1rgi|1rgi]], [[1o19|1o19]], [[1y64|1y64]], [[1alm|1alm]], [[1o1e|1o1e]], [[1esv|1esv]], [[1p8z|1p8z]], [[1h1v|1h1v]], [[1o1c|1o1c]], [[2vcp|2vcp]], [[1o1g|1o1g]], [[2a3z|2a3z]], [[1lot|1lot]], [[2asm|2asm]], [[2a41|2a41]], [[2vyp|2vyp]], [[1qz6|1qz6]], [[2v51|2v51]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=LAB:LATRUNCULIN+B'>LAB</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v52 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v52 OCA], [http://pdbe.org/2v52 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2v52 RCSB], [http://www.ebi.ac.uk/pdbsum/2v52 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2v52 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v52 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v52 OCA], [https://pdbe.org/2v52 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v52 RCSB], [https://www.ebi.ac.uk/pdbsum/2v52 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v52 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ACTS_RABIT ACTS_RABIT]] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. [[http://www.uniprot.org/uniprot/MKL1_MOUSE MKL1_MOUSE]] Transcriptional coactivator of serum response factor (SRF) with the potential to modulate SRF target genes. Suppresses TNF-induced cell death by inhibiting activation of caspases; its transcriptional activity is indispensable for the antiapoptotic function. It may up-regulate antiapoptotic molecules, which in turn inhibit caspase activation.<ref>PMID:19350017</ref>
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[https://www.uniprot.org/uniprot/ACTS_RABIT ACTS_RABIT] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 2v52" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 2v52" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Actin 3D structures|Actin 3D structures]]
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*[[Transcriptional activator 3D structures|Transcriptional activator 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Large Structures]]
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[[Category: Mus musculus]]
[[Category: Oryctolagus cuniculus]]
[[Category: Oryctolagus cuniculus]]
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[[Category: Guettler, S]]
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[[Category: Guettler S]]
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[[Category: Langer, C A]]
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[[Category: Langer CA]]
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[[Category: McDonald, N Q]]
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[[Category: McDonald NQ]]
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[[Category: Mouilleron, S]]
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[[Category: Mouilleron S]]
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[[Category: Treisman, R]]
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[[Category: Treisman R]]
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[[Category: Acetylation]]
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[[Category: Actin]]
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[[Category: Alternative splicing]]
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[[Category: Atp-binding]]
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[[Category: Coiled coil]]
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[[Category: Contractile protein]]
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[[Category: Cytoplasm]]
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[[Category: Cytoskeleton]]
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[[Category: Mal]]
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[[Category: Methylation]]
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[[Category: Muscle protein]]
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[[Category: Nucleotide-binding]]
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[[Category: Nucleus]]
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[[Category: Phosphoprotein]]
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[[Category: Rpel]]
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[[Category: Structural protein]]
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[[Category: Structural protein-contractile protein complex]]
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[[Category: Structural protein/contractile protein]]
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[[Category: Transcription]]
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[[Category: Transcription regulation]]
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Current revision

Structure of MAL-RPEL2 complexed to G-actin

PDB ID 2v52

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