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3fhx

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==Crystal structure of D235A mutant of human pyridoxal kinase==
==Crystal structure of D235A mutant of human pyridoxal kinase==
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<StructureSection load='3fhx' size='340' side='right' caption='[[3fhx]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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<StructureSection load='3fhx' size='340' side='right'caption='[[3fhx]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3fhx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FHX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3FHX FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3fhx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FHX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FHX FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene>, <scene name='pdbligand=PXL:3-HYDROXY-5-(HYDROXYMETHYL)-2-METHYLISONICOTINALDEHYDE'>PXL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3fhy|3fhy]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene>, <scene name='pdbligand=PXL:3-HYDROXY-5-(HYDROXYMETHYL)-2-METHYLISONICOTINALDEHYDE'>PXL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">C21orf124, C21orf97, PDXK, PKH, PNK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fhx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fhx OCA], [https://pdbe.org/3fhx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fhx RCSB], [https://www.ebi.ac.uk/pdbsum/3fhx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fhx ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pyridoxal_kinase Pyridoxal kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.35 2.7.1.35] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fhx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fhx OCA], [http://pdbe.org/3fhx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3fhx RCSB], [http://www.ebi.ac.uk/pdbsum/3fhx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3fhx ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PDXK_HUMAN PDXK_HUMAN]] Required for synthesis of pyridoxal-5-phosphate from vitamin B6.
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[https://www.uniprot.org/uniprot/PDXK_HUMAN PDXK_HUMAN] Required for synthesis of pyridoxal-5-phosphate from vitamin B6.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Pyridoxal kinase]]
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[[Category: Large Structures]]
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[[Category: Gandhi, A K]]
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[[Category: Di Salvo ML]]
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[[Category: Ghatge, M]]
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[[Category: Gandhi AK]]
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[[Category: Musayev, F N]]
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[[Category: Ghatge M]]
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[[Category: Safo, M K]]
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[[Category: Musayev FN]]
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[[Category: Salvo, M L.Di]]
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[[Category: Safo MK]]
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[[Category: Schirch, V]]
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[[Category: Schirch V]]
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[[Category: Atp complex]]
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[[Category: Atp-binding]]
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[[Category: Beta sheet with alpha helix]]
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[[Category: Kinase]]
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[[Category: Metal ion]]
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[[Category: Metal-binding]]
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[[Category: Nucleotide-binding]]
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[[Category: Transferase]]
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Current revision

Crystal structure of D235A mutant of human pyridoxal kinase

PDB ID 3fhx

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