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5fv9

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==Crystal structure of GalNAc-T2 in complex with compound 16d==
==Crystal structure of GalNAc-T2 in complex with compound 16d==
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<StructureSection load='5fv9' size='340' side='right' caption='[[5fv9]], [[Resolution|resolution]] 2.07&Aring;' scene=''>
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<StructureSection load='5fv9' size='340' side='right'caption='[[5fv9]], [[Resolution|resolution]] 2.07&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5fv9]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FV9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FV9 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5fv9]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FV9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FV9 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=UDP:URIDINE-5-DIPHOSPHATE'>UDP</scene>, <scene name='pdbligand=Y6W:[(2R,3S,4R,5R)-5-(2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL+HYDROGEN+(S)-{3-[(2R,3R,4R,5R,6R)-3,4,5-TRIHYDROXY-6-(HYDROXYMETHYL)TETRAHYDRO-2H-PYRAN-2-YL]PROPYL}PHOSPHONATE'>Y6W</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.07&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fv9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fv9 OCA], [http://pdbe.org/5fv9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fv9 RCSB], [http://www.ebi.ac.uk/pdbsum/5fv9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fv9 ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=UDP:URIDINE-5-DIPHOSPHATE'>UDP</scene>, <scene name='pdbligand=Y6W:[(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl+hydrogen+(S)-{3-[(2R,3R,4R,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]propyl}phosphonate'>Y6W</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5fv9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fv9 OCA], [https://pdbe.org/5fv9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5fv9 RCSB], [https://www.ebi.ac.uk/pdbsum/5fv9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5fv9 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/GALT2_HUMAN GALT2_HUMAN]] Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a broad spectrum of substrates for peptides such as EA2, Muc5AC, Muc1a, Muc1b. Probably involved in O-linked glycosylation of the immunoglobulin A1 (IgA1) hinge region.<ref>PMID:9295285</ref> <ref>PMID:12438318</ref>
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[https://www.uniprot.org/uniprot/GALT2_HUMAN GALT2_HUMAN] Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a broad spectrum of substrates for peptides such as EA2, Muc5AC, Muc1a, Muc1b. Probably involved in O-linked glycosylation of the immunoglobulin A1 (IgA1) hinge region.<ref>PMID:9295285</ref> <ref>PMID:12438318</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Delso, I]]
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[[Category: Homo sapiens]]
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[[Category: Ghirardello, M]]
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[[Category: Large Structures]]
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[[Category: Hurtado-Guerrero, R]]
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[[Category: Delso I]]
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[[Category: Lacetera, A]]
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[[Category: Ghirardello M]]
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[[Category: Lira-Navarrete, E]]
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[[Category: Hurtado-Guerrero R]]
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[[Category: Martin-Santamaria, S]]
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[[Category: Lacetera A]]
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[[Category: Merino, P]]
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[[Category: Lira-Navarrete E]]
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[[Category: Rivas, M]]
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[[Category: Martin-Santamaria S]]
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[[Category: Tejero, T]]
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[[Category: Merino P]]
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[[Category: Transferase]]
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[[Category: Rivas M]]
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[[Category: Tejero T]]

Current revision

Crystal structure of GalNAc-T2 in complex with compound 16d

PDB ID 5fv9

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