5fze

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (13:33, 26 July 2023) (edit) (undo)
 
(3 intermediate revisions not shown.)
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 5fze is ON HOLD until Paper Publication
+
==Crystal structure of the catalytic domain of human JARID1B in complex with MC3960==
 +
<StructureSection load='5fze' size='340' side='right'caption='[[5fze]], [[Resolution|resolution]] 2.02&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[5fze]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FZE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FZE FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.02&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=H0X:[(6-OXO-4-PHENYL-1,6-DIHYDROPYRIMIDIN-2-YL)SULFANYL]ACETONITRILE'>H0X</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5fze FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fze OCA], [https://pdbe.org/5fze PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5fze RCSB], [https://www.ebi.ac.uk/pdbsum/5fze PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5fze ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/KDM5B_HUMAN KDM5B_HUMAN] Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma.<ref>PMID:12657635</ref> <ref>PMID:16645588</ref> <ref>PMID:17320161</ref> <ref>PMID:17363312</ref>
-
Authors: Nowak, R., Krojer, T., Johansson, C., Gileadi, C., Kupinska, K., Strain-Damerell, C., Szykowska, A., Von Delft, F., Burgess-Brown, N.A., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Rotili, D., Mai, A., Oppermann, U.
+
==See Also==
-
 
+
*[[Jumonji domain-containing protein 3D structures|Jumonji domain-containing protein 3D structures]]
-
Description: Crystal structure of the catalytic domain of human JARID1B in complex with MC3960
+
*[[Lysine-specific histone demethylase 3D structures|Lysine-specific histone demethylase 3D structures]]
-
[[Category: Unreleased Structures]]
+
== References ==
-
[[Category: Nowak, R]]
+
<references/>
-
[[Category: Arrowsmith, C.H]]
+
__TOC__
-
[[Category: Gileadi, C]]
+
</StructureSection>
-
[[Category: Oppermann, U]]
+
[[Category: Homo sapiens]]
-
[[Category: Rotili, D]]
+
[[Category: Large Structures]]
-
[[Category: Szykowska, A]]
+
[[Category: Arrowsmith CH]]
-
[[Category: Burgess-Brown, N.A]]
+
[[Category: Bountra C]]
-
[[Category: Von Delft, F]]
+
[[Category: Burgess-Brown NA]]
-
[[Category: Edwards, A.M]]
+
[[Category: Edwards AM]]
-
[[Category: Johansson, C]]
+
[[Category: Gileadi C]]
-
[[Category: Mai, A]]
+
[[Category: Johansson C]]
-
[[Category: Strain-Damerell, C]]
+
[[Category: Krojer T]]
-
[[Category: Krojer, T]]
+
[[Category: Kupinska K]]
-
[[Category: Bountra, C]]
+
[[Category: Mai A]]
-
[[Category: Kupinska, K]]
+
[[Category: Nowak R]]
 +
[[Category: Oppermann U]]
 +
[[Category: Rotili D]]
 +
[[Category: Strain-Damerell C]]
 +
[[Category: Szykowska A]]
 +
[[Category: Von Delft F]]

Current revision

Crystal structure of the catalytic domain of human JARID1B in complex with MC3960

PDB ID 5fze

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5fze"
Personal tools