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5g1d

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==The complex structure of syntenin-1 PDZ domain with c-terminal extension==
==The complex structure of syntenin-1 PDZ domain with c-terminal extension==
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<StructureSection load='5g1d' size='340' side='right' caption='[[5g1d]], [[Resolution|resolution]] 2.81&Aring;' scene=''>
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<StructureSection load='5g1d' size='340' side='right'caption='[[5g1d]], [[Resolution|resolution]] 2.81&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5g1d]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5G1D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5G1D FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5g1d]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5G1D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5G1D FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5g1e|5g1e]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.81&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5g1d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5g1d OCA], [http://pdbe.org/5g1d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5g1d RCSB], [http://www.ebi.ac.uk/pdbsum/5g1d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5g1d ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5g1d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5g1d OCA], [https://pdbe.org/5g1d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5g1d RCSB], [https://www.ebi.ac.uk/pdbsum/5g1d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5g1d ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/SDCB1_RAT SDCB1_RAT]] Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis. Positively regulates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signaling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalization and degradation of TGFR1. In concert with SDC1/4 and PDCD6IP, regulates exosome biogenesis. Regulates migration, growth, proliferation, and cell cycle progression in a variety of cancer types. In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA). May also play a role in vesicular trafficking. Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway.[UniProtKB:O00560]
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[https://www.uniprot.org/uniprot/SDCB1_RAT SDCB1_RAT] Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis. Positively regulates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signaling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalization and degradation of TGFR1. In concert with SDC1/4 and PDCD6IP, regulates exosome biogenesis. Regulates migration, growth, proliferation, and cell cycle progression in a variety of cancer types. In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA). May also play a role in vesicular trafficking. Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway.[UniProtKB:O00560]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5g1d" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5g1d" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[3D structures of syntenin|3D structures of syntenin]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Kim, H]]
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[[Category: Large Structures]]
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[[Category: Lee, I]]
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[[Category: Rattus norvegicus]]
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[[Category: Lee, W]]
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[[Category: Kim H]]
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[[Category: Yun, J H]]
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[[Category: Lee I]]
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[[Category: Signaling protein]]
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[[Category: Lee W]]
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[[Category: Yun JH]]

Current revision

The complex structure of syntenin-1 PDZ domain with c-terminal extension

PDB ID 5g1d

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