1a33

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(New page: 200px<br /><applet load="1a33" size="450" color="white" frame="true" align="right" spinBox="true" caption="1a33, resolution 2.15&Aring;" /> '''PEPTIDYLPROLYL ISOME...)
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[[Image:1a33.gif|left|200px]]<br /><applet load="1a33" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1a33, resolution 2.15&Aring;" />
 
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'''PEPTIDYLPROLYL ISOMERASE, CYCLOPHILIN-LIKE DOMAIN FROM BRUGIA MALAYI'''<br />
 
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==Overview==
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==PEPTIDYLPROLYL ISOMERASE, CYCLOPHILIN-LIKE DOMAIN FROM BRUGIA MALAYI==
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Cyclophilins are a family of proteins that exhibit peptidyl-prolyl, cis-trans isomerase activity and bind the immunosuppressive agent, cyclosporin A (CsA). Brugia malayi is a filarial nematode parasite of, humans, for which a cyclophilin-like domain was identified at the, N-terminal of a protein containing 843 amino acid residues. There are two, differences in sequence in the highly conserved CsA binding site: A, histidine and a lysine replace a tryptophan and an alanine, respectively., The crystal structure of this domain has been determined by the molecular, replacement method and refined to an R-factor of 16.9% at 2.15 A, resolution. The overall structure is similar to other cyclophilins;, however, major differences occur in two loops. Comparison of the CsA, binding site of this domain with members of the cyclophilin family shows, significant structural differences, which can account for the reduced, sensitivity of the Brugia malayi protein to inhibition by CsA.
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<StructureSection load='1a33' size='340' side='right'caption='[[1a33]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1a33]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Brugia_malayi Brugia malayi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A33 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1A33 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1a33 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a33 OCA], [https://pdbe.org/1a33 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1a33 RCSB], [https://www.ebi.ac.uk/pdbsum/1a33 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1a33 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CYP1_BRUMA CYP1_BRUMA] PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a3/1a33_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1a33 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Cyclophilins are a family of proteins that exhibit peptidyl-prolyl cis-trans isomerase activity and bind the immunosuppressive agent cyclosporin A (CsA). Brugia malayi is a filarial nematode parasite of humans, for which a cyclophilin-like domain was identified at the N-terminal of a protein containing 843 amino acid residues. There are two differences in sequence in the highly conserved CsA binding site: A histidine and a lysine replace a tryptophan and an alanine, respectively. The crystal structure of this domain has been determined by the molecular replacement method and refined to an R-factor of 16.9% at 2.15 A resolution. The overall structure is similar to other cyclophilins; however, major differences occur in two loops. Comparison of the CsA binding site of this domain with members of the cyclophilin family shows significant structural differences, which can account for the reduced sensitivity of the Brugia malayi protein to inhibition by CsA.
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==About this Structure==
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Crystal structure of the cyclophilin-like domain from the parasitic nematode Brugia malayi.,Mikol V, Ma D, Carlow CK Protein Sci. 1998 Jun;7(6):1310-6. PMID:9655334<ref>PMID:9655334</ref>
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1A33 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Brugia_malayi Brugia malayi]. Active as [http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1A33 OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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Crystal structure of the cyclophilin-like domain from the parasitic nematode Brugia malayi., Mikol V, Ma D, Carlow CK, Protein Sci. 1998 Jun;7(6):1310-6. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9655334 9655334]
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</div>
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<div class="pdbe-citations 1a33" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Brugia malayi]]
[[Category: Brugia malayi]]
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[[Category: Peptidylprolyl isomerase]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Carlow CKS]]
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[[Category: Carlow, C.K.S.]]
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[[Category: Ma D]]
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[[Category: Ma, D.]]
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[[Category: Mikol V]]
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[[Category: Mikol, V.]]
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[[Category: isomerase]]
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[[Category: peptidyl-prolyl cis-trans]]
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[[Category: peptidylprolyl isomerase]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 10:34:50 2007''
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Current revision

PEPTIDYLPROLYL ISOMERASE, CYCLOPHILIN-LIKE DOMAIN FROM BRUGIA MALAYI

PDB ID 1a33

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