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1a6p

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==ENGINEERING OF A MISFOLDED FORM OF CD2==
==ENGINEERING OF A MISFOLDED FORM OF CD2==
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<StructureSection load='1a6p' size='340' side='right' caption='[[1a6p]], [[Resolution|resolution]] 2.08&Aring;' scene=''>
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<StructureSection load='1a6p' size='340' side='right'caption='[[1a6p]], [[Resolution|resolution]] 2.08&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1a6p]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A6P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1A6P FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1a6p]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A6P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1A6P FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1a6p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a6p OCA], [http://pdbe.org/1a6p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1a6p RCSB], [http://www.ebi.ac.uk/pdbsum/1a6p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1a6p ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.08&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1a6p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a6p OCA], [https://pdbe.org/1a6p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1a6p RCSB], [https://www.ebi.ac.uk/pdbsum/1a6p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1a6p ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CD2_RAT CD2_RAT]] CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function.
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[https://www.uniprot.org/uniprot/CD2_RAT CD2_RAT] CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a6/1a6p_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a6/1a6p_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Buffalo rat]]
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[[Category: Large Structures]]
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[[Category: Barker, J J]]
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[[Category: Rattus norvegicus]]
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[[Category: Brady, R L]]
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[[Category: Barker JJ]]
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[[Category: Head, J G]]
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[[Category: Brady RL]]
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[[Category: Murray, A J]]
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[[Category: Head JG]]
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[[Category: Cell adhesion]]
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[[Category: Murray AJ]]
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[[Category: Domain swapping]]
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[[Category: Hinge loop]]
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[[Category: Oligomer evolution]]
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[[Category: T lymphocyte adhesion glycoprotein]]
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Current revision

ENGINEERING OF A MISFOLDED FORM OF CD2

PDB ID 1a6p

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