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1lri

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[[Image:1lri.gif|left|200px]]
[[Image:1lri.gif|left|200px]]
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{{Structure
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|PDB= 1lri |SIZE=350|CAPTION= <scene name='initialview01'>1lri</scene>, resolution 1.45&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>
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{{STRUCTURE_1lri| PDB=1lri | SCENE= }}
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|RELATEDENTRY=[[1beo|1BEO]], [[1bxm|1BXM]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lri FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lri OCA], [http://www.ebi.ac.uk/pdbsum/1lri PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1lri RCSB]</span>
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'''BETA-CRYPTOGEIN-CHOLESTEROL COMPLEX'''
'''BETA-CRYPTOGEIN-CHOLESTEROL COMPLEX'''
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[[Category: Prange, T.]]
[[Category: Prange, T.]]
[[Category: Venard, P.]]
[[Category: Venard, P.]]
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[[Category: cholesterol]]
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[[Category: Cholesterol]]
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[[Category: cryptogein]]
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[[Category: Cryptogein]]
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[[Category: sterol carrier protein]]
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[[Category: Sterol carrier protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:12:47 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:06:26 2008''
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Revision as of 21:12, 2 May 2008

Image:1lri.gif

Template:STRUCTURE 1lri

BETA-CRYPTOGEIN-CHOLESTEROL COMPLEX


Overview

Cryptogein is a small 10 kDa elicitor produced by the phytoparasitic oomycete Phytophthora cryptogea. The protein also displays a sterol carrier activity. The native protein crystallizes in space group P4(1)22, with unit-cell parameters a = b = 46.51, c = 134.9 A (diffraction limit: 2.1 A). Its complex with cholesterol crystallizes in space group C222(1), with unit-cell parameters a = 30.96, b = 94.8, c = 65.3 A and a resolution enhanced to 1.45 A. The large inner non-specific hydrophobic cavity is able to accommodate a large variety of 3-beta-hydroxy sterols. Cryptogein probably acts as a sterol shuttle helping the pathogen to grow and complete its life cycle.

About this Structure

1LRI is a Single protein structure of sequence from Phytophthora cryptogea. Full crystallographic information is available from OCA.

Reference

The 1.45 A resolution structure of the cryptogein-cholesterol complex: a close-up view of a sterol carrier protein (SCP) active site., Lascombe MB, Ponchet M, Venard P, Milat ML, Blein JP, Prange T, Acta Crystallogr D Biol Crystallogr. 2002 Sep;58(Pt 9):1442-7. Epub 2002, Aug 23. PMID:12198300 Page seeded by OCA on Sat May 3 00:12:47 2008

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