This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1bii

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: 200px<br /> <applet load="1bii" size="450" color="white" frame="true" align="right" spinBox="true" caption="1bii, resolution 2.4&Aring;" /> '''THE CRYSTAL STRUCTUR...)
Current revision (11:02, 2 August 2023) (edit) (undo)
 
(17 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1bii.gif|left|200px]]<br />
 
-
<applet load="1bii" size="450" color="white" frame="true" align="right" spinBox="true"
 
-
caption="1bii, resolution 2.4&Aring;" />
 
-
'''THE CRYSTAL STRUCTURE OF H-2DD MHC CLASS I IN COMPLEX WITH THE HIV-1 DERIVED PEPTIDE P18-110'''<br />
 
-
==Overview==
+
==THE CRYSTAL STRUCTURE OF H-2DD MHC CLASS I IN COMPLEX WITH THE HIV-1 DERIVED PEPTIDE P18-110==
-
The structure of H-2Dd complexed with the HIV-derived peptide P18-I10, (RGPGRAFVTI) has been determined by X-ray crystallography at 2.4 A, resolution. This MHC class I molecule has an unusual binding motif with, four anchor residues in the peptide (G2, P3, R/K/H5, and I/L/F9 or 10)., The cleft architecture of H-2Dd includes a deep narrow passage, accomodating the N-terminal part of the peptide, explaining the obligatory, G2P3 anchor motif. Toward the C-terminal half of the peptide, p5R to p8V, form a type I' reverse turn; residues p6A to p9T, and in particular p7F, are readily exposed. The structure is discussed in relation to functional, data available for T cell and natural killer cell recognition of the H-2Dd, molecule.
+
<StructureSection load='1bii' size='340' side='right'caption='[[1bii]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[1bii]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BII OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BII FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bii FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bii OCA], [https://pdbe.org/1bii PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bii RCSB], [https://www.ebi.ac.uk/pdbsum/1bii PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bii ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/HA12_MOUSE HA12_MOUSE] Involved in the presentation of foreign antigens to the immune system.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bi/1bii_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1bii ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
The structure of H-2Dd complexed with the HIV-derived peptide P18-I10 (RGPGRAFVTI) has been determined by X-ray crystallography at 2.4 A resolution. This MHC class I molecule has an unusual binding motif with four anchor residues in the peptide (G2, P3, R/K/H5, and I/L/F9 or 10). The cleft architecture of H-2Dd includes a deep narrow passage accomodating the N-terminal part of the peptide, explaining the obligatory G2P3 anchor motif. Toward the C-terminal half of the peptide, p5R to p8V form a type I' reverse turn; residues p6A to p9T, and in particular p7F, are readily exposed. The structure is discussed in relation to functional data available for T cell and natural killer cell recognition of the H-2Dd molecule.
-
==About this Structure==
+
The crystal structure of H-2Dd MHC class I complexed with the HIV-1-derived peptide P18-I10 at 2.4 A resolution: implications for T cell and NK cell recognition.,Achour A, Persson K, Harris RA, Sundback J, Sentman CL, Lindqvist Y, Schneider G, Karre K Immunity. 1998 Aug;9(2):199-208. PMID:9729040<ref>PMID:9729040</ref>
-
1BII is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1BII OCA].
+
-
==Reference==
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
The crystal structure of H-2Dd MHC class I complexed with the HIV-1-derived peptide P18-I10 at 2.4 A resolution: implications for T cell and NK cell recognition., Achour A, Persson K, Harris RA, Sundback J, Sentman CL, Lindqvist Y, Schneider G, Karre K, Immunity. 1998 Aug;9(2):199-208. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9729040 9729040]
+
</div>
-
[[Category: Mus musculus]]
+
<div class="pdbe-citations 1bii" style="background-color:#fffaf0;"></div>
-
[[Category: Protein complex]]
+
-
[[Category: Achour, A.]]
+
-
[[Category: Harris, R.A.]]
+
-
[[Category: Karre, K.]]
+
-
[[Category: Lindqvist, Y.]]
+
-
[[Category: Persson, K.]]
+
-
[[Category: Schneider, G.]]
+
-
[[Category: Sentman, C.L.]]
+
-
[[Category: Sundback, J.]]
+
-
[[Category: complex (mhc i/peptide)]]
+
-
[[Category: glycoprotein]]
+
-
[[Category: major histocompatibility complex class i dd]]
+
-
[[Category: transmembrane]]
+
-
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Thu Nov 8 13:53:40 2007''
+
==See Also==
 +
*[[Beta-2 microglobulin 3D structures|Beta-2 microglobulin 3D structures]]
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Large Structures]]
 +
[[Category: Mus musculus]]
 +
[[Category: Achour A]]
 +
[[Category: Harris RA]]
 +
[[Category: Karre K]]
 +
[[Category: Lindqvist Y]]
 +
[[Category: Persson K]]
 +
[[Category: Schneider G]]
 +
[[Category: Sentman CL]]
 +
[[Category: Sundback J]]

Current revision

THE CRYSTAL STRUCTURE OF H-2DD MHC CLASS I IN COMPLEX WITH THE HIV-1 DERIVED PEPTIDE P18-110

PDB ID 1bii

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1bii"
Personal tools