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5ltl
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of human chemokine CCL16== | |
| - | + | <StructureSection load='5ltl' size='340' side='right'caption='[[5ltl]], [[Resolution|resolution]] 1.45Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5ltl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LTL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5LTL FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.45Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ltl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ltl OCA], [https://pdbe.org/5ltl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ltl RCSB], [https://www.ebi.ac.uk/pdbsum/5ltl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ltl ProSAT]</span></td></tr> |
| - | [[Category: Haenel | + | </table> |
| - | [[Category: Weiergraeber | + | == Function == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/CCL16_HUMAN CCL16_HUMAN] Shows chemotactic activity for lymphocytes and monocytes but not neutrophils. Also shows potent myelosuppressive activity, suppresses proliferation of myeloid progenitor cells. Recombinant SCYA16 shows chemotactic activity for monocytes and THP-1 monocytes, but not for resting lymphocytes and neutrophils. Induces a calcium flux in THP-1 cells that were desensitized by prior expression to RANTES. |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Batra-Safferling R]] | ||
| + | [[Category: Haenel K]] | ||
| + | [[Category: Weiergraeber OH]] | ||
| + | [[Category: Willbold D]] | ||
Current revision
Structure of human chemokine CCL16
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