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7wz8
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 7wz8 is ON HOLD Authors: Oda, T., Yanagisawa, H. Description: Structure of human langerin complex in Birbeck granules [[Category: Unreleased Struct...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of human langerin complex in Birbeck granules== | |
| - | + | <StructureSection load='7wz8' size='340' side='right'caption='[[7wz8]], [[Resolution|resolution]] 6.40Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[7wz8]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7WZ8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7WZ8 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 6.4Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7wz8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7wz8 OCA], [https://pdbe.org/7wz8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7wz8 RCSB], [https://www.ebi.ac.uk/pdbsum/7wz8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7wz8 ProSAT]</span></td></tr> |
| - | [[Category: Oda | + | </table> |
| - | [[Category: Yanagisawa | + | == Disease == |
| + | [https://www.uniprot.org/uniprot/CLC4K_HUMAN CLC4K_HUMAN] Defects in CD207 are the cause of Birbeck granule deficiency (BIRGD) [MIM:[https://omim.org/entry/613393 613393]. It is a condition characterized by the absence of Birbeck granules in epidermal Langerhans cells. Despite the lack of Birbeck granules Langerhans cells are present in normal numbers and have normal morphologic characteristics and antigen-presenting capacity.<ref>PMID:15816828</ref> <ref>PMID:16567809</ref> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CLC4K_HUMAN CLC4K_HUMAN] Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells. Major receptor on primary Langerhans cells for Candida species, Saccharomyces species, and Malassezia furfur. Protects against human immunodeficiency virus-1 (HIV-1) infection. Binds to high-mannose structures present on the envelope glycoprotein which is followed by subsequent targeting of the virus to the Birbeck granules leading to its rapid degradation.<ref>PMID:10661407</ref> <ref>PMID:17334373</ref> <ref>PMID:20026605</ref> <ref>PMID:20097424</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Oda T]] | ||
| + | [[Category: Yanagisawa H]] | ||
Current revision
Structure of human langerin complex in Birbeck granules
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