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1szh

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[[Image:1szh.png|left|200px]]
 
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{{STRUCTURE_1szh| PDB=1szh | SCENE= }}
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==Crystal Structure of C. elegans HER-1==
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<StructureSection load='1szh' size='340' side='right'caption='[[1szh]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1szh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SZH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SZH FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1szh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1szh OCA], [https://pdbe.org/1szh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1szh RCSB], [https://www.ebi.ac.uk/pdbsum/1szh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1szh ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HER1_CAEEL HER1_CAEEL] Dictates male development. Probably plays a direct role in cell signaling during C.elegans sex determination. Inhibits the function of tra-2a.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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HER-1 is a secreted protein that promotes male development in the nematode Caenorhabditis elegans. HER-1 inhibits the function of TRA-2A, a multipass integral membrane protein thought to serve as its receptor. We report here the 1.5-A crystal structure of HER-1. The structure was solved by the multiwavelength anomalous diffraction method by using selenomethionyl-substituted HER-1 produced in Chinese hamster ovary cells. The HER-1 structure consists of two all-helical domains and is not closely homologous to any known structure. Sites of amino acid substitutions known to impair HER-1 function were mapped on the HER-1 structure and classified according to the likely mechanism by which they affect HER-1 activity. A subset of these and other amino acid substitutions on the HER-1 surface were assayed for their ability to disrupt interactions between HER-1 and TRA-2A-expressing cells, and a localized region on the HER-1 surface important for mediating this interaction was identified.
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===Crystal Structure of C. elegans HER-1===
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Crystal structure of Caenorhabditis elegans HER-1 and characterization of the interaction between HER-1 and TRA-2A.,Hamaoka BY, Dann CE 3rd, Geisbrecht BV, Leahy DJ Proc Natl Acad Sci U S A. 2004 Aug 10;101(32):11673-8. Epub 2004 Aug 2. PMID:15289613<ref>PMID:15289613</ref>
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{{ABSTRACT_PUBMED_15289613}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 1szh" style="background-color:#fffaf0;"></div>
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[[1szh]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SZH OCA].
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Caenorhabditis elegans]]
[[Category: Caenorhabditis elegans]]
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[[Category: Geisbrecht, B V.]]
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[[Category: Large Structures]]
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[[Category: Hamaoka, B Y.]]
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[[Category: Dann III CE]]
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[[Category: III, C E.Dann.]]
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[[Category: Geisbrecht BV]]
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[[Category: Leahy, D J.]]
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[[Category: Hamaoka BY]]
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[[Category: Extended 3-10 helix]]
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[[Category: Leahy DJ]]
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[[Category: Left-handed anti-parallel 4-helix bundle]]
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[[Category: Overhand 3-helix bundle]]
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[[Category: Signaling protein]]
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Current revision

Crystal Structure of C. elegans HER-1

PDB ID 1szh

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