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5gi9

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<StructureSection load='5gi9' size='340' side='right'caption='[[5gi9]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
<StructureSection load='5gi9' size='340' side='right'caption='[[5gi9]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5gi9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GI9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5GI9 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5gi9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GI9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5GI9 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7AN:~{N}-[2-(1~{H}-indol-3-yl)ethyl]ethanamide'>7AN</scene>, <scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=D1D:(4S,5S)-1,2-DITHIANE-4,5-DIOL'>D1D</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[5gi5|5gi5]], [[5gi6|5gi6]], [[5gi7|5gi7]], [[5gi8|5gi8]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7AN:~{N}-[2-(1~{H}-indol-3-yl)ethyl]ethanamide'>7AN</scene>, <scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=D1D:(4S,5S)-1,2-DITHIANE-4,5-DIOL'>D1D</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Dat, NAT1, CG3318 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Aralkylamine_N-acetyltransferase Aralkylamine N-acetyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.87 2.3.1.87] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5gi9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gi9 OCA], [https://pdbe.org/5gi9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5gi9 RCSB], [https://www.ebi.ac.uk/pdbsum/5gi9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5gi9 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5gi9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gi9 OCA], [https://pdbe.org/5gi9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5gi9 RCSB], [https://www.ebi.ac.uk/pdbsum/5gi9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5gi9 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/DNAT_DROME DNAT_DROME]] Catalyzes N-acetylation of tryptamine, tyramine, dopamine, serotonin and octopamine. Is not essential for sclerotization.<ref>PMID:8901578</ref> <ref>PMID:9703021</ref> <ref>PMID:7498465</ref>
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[https://www.uniprot.org/uniprot/DNAT_DROME DNAT_DROME] Catalyzes N-acetylation of tryptamine, tyramine, dopamine, serotonin and octopamine. Is not essential for sclerotization.<ref>PMID:8901578</ref> <ref>PMID:9703021</ref> <ref>PMID:7498465</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Aralkylamine N-acetyltransferase]]
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[[Category: Drosophila melanogaster]]
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[[Category: Drome]]
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[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Cheng, H C]]
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[[Category: Cheng HC]]
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[[Category: Cheng, K C]]
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[[Category: Cheng KC]]
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[[Category: Lin, S J]]
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[[Category: Lin SJ]]
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[[Category: Lyu, P C]]
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[[Category: Lyu PC]]
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[[Category: Yang, Y C]]
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[[Category: Yang YC]]
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[[Category: Order bi-bi sequential mechanism]]
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[[Category: Transferase]]
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Revision as of 11:32, 2 August 2023

Crystal Structure of Drosophila melanogaster Dopamine N-Acetyltransferase in Ternary Complex with CoA and Acetyl-Tryptamine

PDB ID 5gi9

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