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5gu4

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Current revision (11:42, 2 August 2023) (edit) (undo)
 
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<StructureSection load='5gu4' size='340' side='right'caption='[[5gu4]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
<StructureSection load='5gu4' size='340' side='right'caption='[[5gu4]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5gu4]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Castor_bean Castor bean]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GU4 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5GU4 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5gu4]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Ricinus_communis Ricinus communis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GU4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5GU4 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.55&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/rRNA_N-glycosylase rRNA N-glycosylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.22 3.2.2.22] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5gu4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gu4 OCA], [http://pdbe.org/5gu4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5gu4 RCSB], [http://www.ebi.ac.uk/pdbsum/5gu4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5gu4 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5gu4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gu4 OCA], [https://pdbe.org/5gu4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5gu4 RCSB], [https://www.ebi.ac.uk/pdbsum/5gu4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5gu4 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/RICI_RICCO RICI_RICCO]] Ricin is highly toxic to animal cells and to a lesser extent to plant cells. The A chain acts as a glycosidase that removes a specific adenine residue from an exposed loop of the 28S rRNA (A4324 in mammals), leading to rRNA breakage. As this loop is involved in elongation factor binding, modified ribosomes are catalytically inactive and unable to support protein synthesis. The A chain can inactivate a few thousand ribosomes per minute, faster than the cell can make new ones. Therefore a single A chain molecule can kill an animal cell. The B chain binds to beta-D-galactopyranoside moieties on cell surface glycoproteins and glycolipids and facilitates the entry into the cell of the A chain; B chains are also responsible for cell agglutination (Lectin activity).
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[https://www.uniprot.org/uniprot/RLA2_HUMAN RLA2_HUMAN] Plays an important role in the elongation step of protein synthesis.[HAMAP-Rule:MF_01478]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[Ricin|Ricin]]
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*[[Ricin 3D structures|Ricin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Castor bean]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: RRNA N-glycosylase]]
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[[Category: Ricinus communis]]
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[[Category: Shaw, P C]]
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[[Category: Shaw PC]]
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[[Category: Shi, W W]]
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[[Category: Shi WW]]
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[[Category: Sze, S Y]]
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[[Category: Sze SY]]
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[[Category: Tang, Y S]]
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[[Category: Tang YS]]
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[[Category: Wong, K B]]
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[[Category: Wong KB]]
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[[Category: Zhu, Z N]]
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[[Category: Zhu ZN]]
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[[Category: Hydrolase]]
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[[Category: Ribosomal p stalk protein]]
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[[Category: Ribosome]]
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[[Category: Ribosome-inactivating protein]]
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[[Category: Ricin]]
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Current revision

rRNA N-glycosylase RTA

PDB ID 5gu4

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