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1bt6

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[[Image:1bt6.png|left|200px]]
 
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{{STRUCTURE_1bt6| PDB=1bt6 | SCENE= }}
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==P11 (S100A10), LIGAND OF ANNEXIN II IN COMPLEX WITH ANNEXIN II N-TERMINUS==
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<StructureSection load='1bt6' size='340' side='right'caption='[[1bt6]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1bt6]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BT6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BT6 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bt6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bt6 OCA], [https://pdbe.org/1bt6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bt6 RCSB], [https://www.ebi.ac.uk/pdbsum/1bt6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bt6 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/S10AA_HUMAN S10AA_HUMAN] Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bt/1bt6_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1bt6 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The aggregation and membrane fusion properties of annexin II are modulated by the association with a regulatory light chain called p11.p11 is a member of the S100 EF-hand protein family, which is unique in having lost its calcium-binding properties. We report the first structure of a complex between p11 and its cognate peptide, the N-terminus of annexin II, as well as that of p11 alone. The basic unit for p11 is a tight, non-covalent dimer. In the complex, each annexin II peptide forms hydrophobic interactions with both p11 monomers, thus providing a structural basis for high affinity interactions between an S100 protein and its target sequence. Finally, p11 forms a disulfide-linked tetramer in both types of crystals thus suggesting a model for an oxidized form of other S100 proteins that have been found in the extracellular milieu.
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===P11 (S100A10), LIGAND OF ANNEXIN II IN COMPLEX WITH ANNEXIN II N-TERMINUS===
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The crystal structure of a complex of p11 with the annexin II N-terminal peptide.,Rety S, Sopkova J, Renouard M, Osterloh D, Gerke V, Tabaries S, Russo-Marie F, Lewit-Bentley A Nat Struct Biol. 1999 Jan;6(1):89-95. PMID:9886297<ref>PMID:9886297</ref>
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{{ABSTRACT_PUBMED_9886297}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 1bt6" style="background-color:#fffaf0;"></div>
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[[1bt6]] is a 4 chain structure of [[Annexin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BT6 OCA].
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==See Also==
==See Also==
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*[[Annexin|Annexin]]
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*[[Annexin 3D structures|Annexin 3D structures]]
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*[[S100 proteins 3D structures|S100 proteins 3D structures]]
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==Reference==
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== References ==
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<ref group="xtra">PMID:009886297</ref><ref group="xtra">PMID:017607745</ref><references group="xtra"/>
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Gerke, V.]]
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[[Category: Large Structures]]
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[[Category: Lewit-Bentley, A.]]
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[[Category: Gerke V]]
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[[Category: Osterloh, D.]]
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[[Category: Lewit-Bentley A]]
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[[Category: Renouard, M.]]
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[[Category: Osterloh D]]
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[[Category: Rety, S.]]
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[[Category: Renouard M]]
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[[Category: Russo-Marie, F.]]
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[[Category: Rety S]]
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[[Category: Sopkova, J.]]
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[[Category: Russo-Marie F]]
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[[Category: Calcium/phospholipid binding protein]]
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[[Category: Sopkova J]]
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[[Category: Ef-hand protein]]
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[[Category: Ligand of annexin ii]]
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[[Category: S100 family]]
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Current revision

P11 (S100A10), LIGAND OF ANNEXIN II IN COMPLEX WITH ANNEXIN II N-TERMINUS

PDB ID 1bt6

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