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1dg6

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==CRYSTAL STRUCTURE OF APO2L/TRAIL==
==CRYSTAL STRUCTURE OF APO2L/TRAIL==
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<StructureSection load='1dg6' size='340' side='right' caption='[[1dg6]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
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<StructureSection load='1dg6' size='340' side='right'caption='[[1dg6]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1dg6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DG6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DG6 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1dg6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DG6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DG6 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dg6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dg6 OCA], [http://pdbe.org/1dg6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1dg6 RCSB], [http://www.ebi.ac.uk/pdbsum/1dg6 PDBsum]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dg6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dg6 OCA], [https://pdbe.org/1dg6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dg6 RCSB], [https://www.ebi.ac.uk/pdbsum/1dg6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dg6 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/TNF10_HUMAN TNF10_HUMAN]] Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis.
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[https://www.uniprot.org/uniprot/TNF10_HUMAN TNF10_HUMAN] Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dg/1dg6_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dg/1dg6_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: ConnelL, M P.O]]
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[[Category: Large Structures]]
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[[Category: Hymowitz, S G]]
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[[Category: Hymowitz SG]]
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[[Category: Kelley, R F]]
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[[Category: Kelley RF]]
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[[Category: Ultsch, M H]]
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[[Category: O'ConnelL MP]]
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[[Category: Vos, A M.de]]
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[[Category: Ultsch MH]]
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[[Category: Apoptosis]]
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[[Category: De Vos AM]]
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[[Category: Cytokine]]
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[[Category: Tnf]]
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[[Category: Trimer]]
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[[Category: Zinc-binding site]]
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Current revision

CRYSTAL STRUCTURE OF APO2L/TRAIL

PDB ID 1dg6

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