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1fhx

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==Structure of the pleckstrin homology domain from GRP1 in complex with inositol 1,3,4,5-tetrakisphosphate==
==Structure of the pleckstrin homology domain from GRP1 in complex with inositol 1,3,4,5-tetrakisphosphate==
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<StructureSection load='1fhx' size='340' side='right' caption='[[1fhx]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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<StructureSection load='1fhx' size='340' side='right'caption='[[1fhx]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1fhx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FHX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1FHX FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1fhx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FHX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FHX FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4IP:INOSITOL-(1,3,4,5)-TETRAKISPHOSPHATE'>4IP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4IP:INOSITOL-(1,3,4,5)-TETRAKISPHOSPHATE'>4IP</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1fhw|1fhw]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fhx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fhx OCA], [https://pdbe.org/1fhx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fhx RCSB], [https://www.ebi.ac.uk/pdbsum/1fhx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fhx ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fhx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fhx OCA], [http://pdbe.org/1fhx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1fhx RCSB], [http://www.ebi.ac.uk/pdbsum/1fhx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1fhx ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CYH3_MOUSE CYH3_MOUSE]] Promotes guanine-nucleotide exchange on ARF1. Promotes the activation of ARF factors through replacement of GDP with GTP.<ref>PMID:18042453</ref>
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[https://www.uniprot.org/uniprot/CYH3_MOUSE CYH3_MOUSE] Promotes guanine-nucleotide exchange on ARF1. Promotes the activation of ARF factors through replacement of GDP with GTP.<ref>PMID:18042453</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Lk3 transgenic mice]]
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[[Category: Large Structures]]
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[[Category: Ferguson, K M]]
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[[Category: Mus musculus]]
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[[Category: Fournier, E]]
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[[Category: Ferguson KM]]
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[[Category: Isakoff, S J]]
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[[Category: Fournier E]]
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[[Category: Kavran, J M]]
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[[Category: Isakoff SJ]]
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[[Category: Lemmon, M A]]
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[[Category: Kavran JM]]
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[[Category: Sankaran, V G]]
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[[Category: Lemmon MA]]
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[[Category: Skolnik, E Y]]
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[[Category: Sankaran VG]]
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[[Category: 3-phosphoinositide]]
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[[Category: Skolnik EY]]
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[[Category: Guanine nucleotide exchange factor]]
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[[Category: Inositol tetrakisphosphate signal transduction protein]]
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[[Category: Pleckstrin]]
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[[Category: Signaling protein]]
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Current revision

Structure of the pleckstrin homology domain from GRP1 in complex with inositol 1,3,4,5-tetrakisphosphate

PDB ID 1fhx

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