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1hdm

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[[Image:1hdm.jpg|left|200px]]<br /><applet load="1hdm" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="1hdm, resolution 2.5&Aring;" />
 
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'''HISTOCOMPATIBILITY ANTIGEN HLA-DM'''<br />
 
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==Overview==
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==HISTOCOMPATIBILITY ANTIGEN HLA-DM==
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The three-dimensional structure of the soluble ecto-domain of HLA-DM has, been determined to 2.5 A resolution by X-ray crystallography. HLA-DM has, both peptide exchange activity and acts as a chaperone to peptide-free, class II MHC molecules. As predicted, the structure is similar to that of, classical class II MHC molecules except that the peptide-binding site is, altered to an almost fully closed groove. An unusual cavity is found at, the center of the region that binds peptides in class II MHC molecules, and a tryptophanrich lateral surface is identified that is a candidate, both for binding to HLA-DR, to effect catalysis, and to HLA-DO, an, inhibitor.
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<StructureSection load='1hdm' size='340' side='right'caption='[[1hdm]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1hdm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HDM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HDM FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hdm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hdm OCA], [https://pdbe.org/1hdm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hdm RCSB], [https://www.ebi.ac.uk/pdbsum/1hdm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hdm ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DMA_HUMAN DMA_HUMAN] Plays a critical role in catalyzing the release of class II-associated invariant chain peptide (CLIP) from newly synthesized MHC class II molecules and freeing the peptide binding site for acquisition of antigenic peptides. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO.<ref>PMID:8849454</ref> <ref>PMID:9768757</ref> <ref>PMID:16547258</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hd/1hdm_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hdm ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The three-dimensional structure of the soluble ecto-domain of HLA-DM has been determined to 2.5 A resolution by X-ray crystallography. HLA-DM has both peptide exchange activity and acts as a chaperone to peptide-free class II MHC molecules. As predicted, the structure is similar to that of classical class II MHC molecules except that the peptide-binding site is altered to an almost fully closed groove. An unusual cavity is found at the center of the region that binds peptides in class II MHC molecules, and a tryptophanrich lateral surface is identified that is a candidate both for binding to HLA-DR, to effect catalysis, and to HLA-DO, an inhibitor.
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==Disease==
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The structure of HLA-DM, the peptide exchange catalyst that loads antigen onto class II MHC molecules during antigen presentation.,Mosyak L, Zaller DM, Wiley DC Immunity. 1998 Sep;9(3):377-83. PMID:9768757<ref>PMID:9768757</ref>
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Known diseases associated with this structure: Branchiootorenal syndrome 2 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=600963 600963]], Glioblastoma multiforme, somatic OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=601969 601969]], Medulloblastoma OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=601969 601969]]
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==About this Structure==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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1HDM is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HDM OCA].
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</div>
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<div class="pdbe-citations 1hdm" style="background-color:#fffaf0;"></div>
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==Reference==
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==See Also==
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The structure of HLA-DM, the peptide exchange catalyst that loads antigen onto class II MHC molecules during antigen presentation., Mosyak L, Zaller DM, Wiley DC, Immunity. 1998 Sep;9(3):377-83. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9768757 9768757]
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*[[MHC 3D structures|MHC 3D structures]]
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*[[MHC II 3D structures|MHC II 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Protein complex]]
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[[Category: Large Structures]]
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[[Category: Mosyak, L.]]
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[[Category: Mosyak L]]
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[[Category: Wiley, D.C.]]
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[[Category: Wiley DC]]
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[[Category: histocompatibility protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 15:56:10 2008''
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Current revision

HISTOCOMPATIBILITY ANTIGEN HLA-DM

PDB ID 1hdm

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