1lwc

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[[Image:1lwc.jpg|left|200px]]
[[Image:1lwc.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1lwc |SIZE=350|CAPTION= <scene name='initialview01'>1lwc</scene>, resolution 2.62&Aring;
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The line below this paragraph, containing "STRUCTURE_1lwc", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene>, <scene name='pdbligand=NVP:11-CYCLOPROPYL-5,11-DIHYDRO-4-METHYL-6H-DIPYRIDO[3,2-B&#58;2&#39;,3&#39;-E][1,4]DIAZEPIN-6-ONE'>NVP</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA-directed_DNA_polymerase RNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.49 2.7.7.49] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= HIV-1 POL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 Human immunodeficiency virus 1])
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-->
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|DOMAIN=
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{{STRUCTURE_1lwc| PDB=1lwc | SCENE= }}
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|RELATEDENTRY=[[1vrt|1VRT]], [[1rth|1RTH]], [[1vru|1VRU]], [[1rti|1RTI]], [[1rtj|1RTJ]], [[1rev|1REV]], [[1rt1|1RT1]], [[1rt2|1RT2]], [[1klm|1KLM]], [[1rt3|1RT3]], [[1rt4|1RT4]], [[1rt5|1RT5]], [[1rt6|1RT6]], [[1rt7|1RT7]], [[1c0t|1C0T]], [[1c0u|1C0U]], [[1c1b|1C1B]], [[1c1c|1C1C]], [[1dtq|1DTQ]], [[1dtt|1DTT]], [[1ep4|1EP4]], [[1fk9|1FK9]], [[1fko|1FKO]], [[1fkp|1FKP]], [[1jla|1JLA]], [[1jlb|1JLB]], [[1jlc|1JLC]], [[1jle|1JLE]], [[1jlf|1JLF]], [[1jlg|1JLG]], [[1jkh|1JKH]], [[1jlq|1JLQ]], [[1lw0|1LW0]], [[1lw2|1LW2]], [[1lwe|1LWE]], [[1lwf|1LWF]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lwc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lwc OCA], [http://www.ebi.ac.uk/pdbsum/1lwc PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1lwc RCSB]</span>
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}}
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'''CRYSTAL STRUCTURE OF M184V MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH NEVIRAPINE'''
'''CRYSTAL STRUCTURE OF M184V MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH NEVIRAPINE'''
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[[Category: Stuart, D I.]]
[[Category: Stuart, D I.]]
[[Category: 3tc]]
[[Category: 3tc]]
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[[Category: aid]]
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[[Category: Aid]]
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[[Category: azt]]
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[[Category: Azt]]
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[[Category: drug resistance mutation]]
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[[Category: Drug resistance mutation]]
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[[Category: hiv-1 reverse transcriptase]]
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[[Category: Hiv-1 reverse transcriptase]]
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[[Category: nevirapine]]
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[[Category: Nevirapine]]
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[[Category: nrti]]
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[[Category: Nrti]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:21:47 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:08:16 2008''
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Revision as of 21:21, 2 May 2008

Image:1lwc.jpg

Template:STRUCTURE 1lwc

CRYSTAL STRUCTURE OF M184V MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH NEVIRAPINE


Overview

Six structures of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) containing combinations of resistance mutations for zidovudine (AZT) (M41L and T215Y) or lamivudine (M184V) have been determined as inhibitor complexes. Minimal conformational changes in the polymerase or nonnucleoside RT inhibitor sites compared to the mutant RTMC (D67N, K70R, T215F, and K219N) are observed, indicating that such changes may occur only with certain combinations of mutations. Model building M41L and T215Y into HIV-1 RT-DNA and docking in ATP that is utilized in the pyrophosphorolysis reaction for AZT resistance indicates that some conformational rearrangement appears necessary in RT for ATP to interact simultaneously with the M41L and T215Y mutations.

About this Structure

1LWC is a Protein complex structure of sequences from Human immunodeficiency virus 1. Full crystallographic information is available from OCA.

Reference

Crystal structures of Zidovudine- or Lamivudine-resistant human immunodeficiency virus type 1 reverse transcriptases containing mutations at codons 41, 184, and 215., Chamberlain PP, Ren J, Nichols CE, Douglas L, Lennerstrand J, Larder BA, Stuart DI, Stammers DK, J Virol. 2002 Oct;76(19):10015-9. PMID:12208978 Page seeded by OCA on Sat May 3 00:21:47 2008

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OCA

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