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1i47

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[[Image:1i47.png|left|200px]]
 
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{{STRUCTURE_1i47| PDB=1i47 | SCENE= }}
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==MOLECULAR AND CRYSTAL STRUCTURE OF D(CGCGAATT(MO4)CGCG): THE WATSON-CRICK TYPE AND WOBBLE N4-METHOXYCYTIDINE/GUANOSINE BASE PAIRS IN B-DNA==
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<StructureSection load='1i47' size='340' side='right'caption='[[1i47]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1i47]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I47 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1I47 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C45:N4-METHOXY-2-DEOXY-CYTIDINE-5-MONOPHOSPHATE'>C45</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1i47 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i47 OCA], [https://pdbe.org/1i47 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1i47 RCSB], [https://www.ebi.ac.uk/pdbsum/1i47 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1i47 ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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To investigate the mutation mechanism of purine transition in DNA damaged with methoxyamine, a DNA dodecamer with the sequence d(CGCGAATTmo(4)CGCG), where mo(4)C is 2'-deoxy-N(4)-methoxycytidine, has been synthesized and its crystal structure determined. Two dodecamers form a B-form duplex. Electron density maps clearly show that one of the two mo(4)C residues forms a pair with a guanine residue of the opposite strand, the geometry being the canonical Watson-Crick type, and that the other mo(4)C residue forms a wobble pair with the opposite guanine residue. These two pairings are ascribed to the tautomerization of the methoxylated cytosine moieties between the amino and imino forms.
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===MOLECULAR AND CRYSTAL STRUCTURE OF D(CGCGAATT(MO4)CGCG): THE WATSON-CRICK TYPE AND WOBBLE N4-METHOXYCYTIDINE/GUANOSINE BASE PAIRS IN B-DNA===
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Crystallographic studies on damaged DNAs: III. N(4)-methoxycytosine can form both Watson-Crick type and wobbled base pairs in a B-form duplex.,Hossain MT, Chatake T, Hikima T, Tsunoda M, Sunami T, Ueno Y, Matsuda A, Takenaka A J Biochem. 2001 Jul;130(1):9-12. PMID:11432773<ref>PMID:11432773</ref>
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{{ABSTRACT_PUBMED_11432773}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 1i47" style="background-color:#fffaf0;"></div>
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[[1i47]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I47 OCA].
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== References ==
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[[Category: Chatake, T.]]
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<references/>
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[[Category: Hikima, T.]]
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__TOC__
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[[Category: Hossain, M T.]]
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</StructureSection>
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[[Category: Matsuda, A.]]
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[[Category: Large Structures]]
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[[Category: Sunami, T.]]
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[[Category: Chatake T]]
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[[Category: Takenaka, A.]]
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[[Category: Hikima T]]
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[[Category: Tsunoda, M.]]
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[[Category: Hossain MT]]
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[[Category: Ueno, Y.]]
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[[Category: Matsuda A]]
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[[Category: B-dna]]
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[[Category: Sunami T]]
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[[Category: Damaged dna]]
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[[Category: Takenaka A]]
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[[Category: Deoxyribonucleic acid]]
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[[Category: Tsunoda M]]
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[[Category: Dna]]
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[[Category: Ueno Y]]
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[[Category: Double helix]]
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[[Category: N4-methoxycytosine]]
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Current revision

MOLECULAR AND CRYSTAL STRUCTURE OF D(CGCGAATT(MO4)CGCG): THE WATSON-CRICK TYPE AND WOBBLE N4-METHOXYCYTIDINE/GUANOSINE BASE PAIRS IN B-DNA

PDB ID 1i47

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