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1ieb

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(New page: 200px<br /><applet load="1ieb" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ieb, resolution 2.7&Aring;" /> '''HISTOCOMPATIBILITY AN...)
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[[Image:1ieb.gif|left|200px]]<br /><applet load="1ieb" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1ieb, resolution 2.7&Aring;" />
 
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'''HISTOCOMPATIBILITY ANTIGEN'''<br />
 
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==Overview==
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==HISTOCOMPATIBILITY ANTIGEN==
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The high-resolution x-ray crystal structures of the murine major, histocompatibility complex (MHC) class II molecule, I-E(k), occupied by, either of two antigenic peptides were determined. They reveal the, structural basis for the I-E(k) peptide binding motif and suggest general, principles for additional alleles. A buried cluster of acidic amino acids, in the binding groove predicted to be conserved among all murine I-E and, human DR MHC class II molecules suggests how pH may influence MHC binding, or exchange of peptides. These structures also complement mutational, studies on the importance of individual peptide residues to T cell, receptor recognition.
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<StructureSection load='1ieb' size='340' side='right'caption='[[1ieb]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1ieb]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IEB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IEB FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ieb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ieb OCA], [https://pdbe.org/1ieb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ieb RCSB], [https://www.ebi.ac.uk/pdbsum/1ieb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ieb ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q31164_MOUSE Q31164_MOUSE]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ie/1ieb_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ieb ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The high-resolution x-ray crystal structures of the murine major histocompatibility complex (MHC) class II molecule, I-E(k), occupied by either of two antigenic peptides were determined. They reveal the structural basis for the I-E(k) peptide binding motif and suggest general principles for additional alleles. A buried cluster of acidic amino acids in the binding groove predicted to be conserved among all murine I-E and human DR MHC class II molecules suggests how pH may influence MHC binding or exchange of peptides. These structures also complement mutational studies on the importance of individual peptide residues to T cell receptor recognition.
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==About this Structure==
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Structures of an MHC class II molecule with covalently bound single peptides.,Fremont DH, Hendrickson WA, Marrack P, Kappler J Science. 1996 May 17;272(5264):1001-4. PMID:8638119<ref>PMID:8638119</ref>
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1IEB is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with NAG, NDG and SO4 as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1IEB OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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Structures of an MHC class II molecule with covalently bound single peptides., Fremont DH, Hendrickson WA, Marrack P, Kappler J, Science. 1996 May 17;272(5264):1001-4. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8638119 8638119]
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</div>
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[[Category: Mus musculus]]
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<div class="pdbe-citations 1ieb" style="background-color:#fffaf0;"></div>
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[[Category: Protein complex]]
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[[Category: Fremont, D.H.]]
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[[Category: Hendrickson, W.A.]]
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[[Category: Kappler, J.]]
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[[Category: Marrack, P.]]
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[[Category: NAG]]
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[[Category: NDG]]
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[[Category: SO4]]
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[[Category: histocompatibility antigen]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 17:20:20 2007''
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==See Also==
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*[[MHC 3D structures|MHC 3D structures]]
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*[[MHC II 3D structures|MHC II 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Mus musculus]]
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[[Category: Fremont DH]]
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[[Category: Hendrickson WA]]
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[[Category: Kappler J]]
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[[Category: Marrack P]]

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HISTOCOMPATIBILITY ANTIGEN

PDB ID 1ieb

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