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1iol

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Current revision (06:26, 9 August 2023) (edit) (undo)
 
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<StructureSection load='1iol' size='340' side='right'caption='[[1iol]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='1iol' size='340' side='right'caption='[[1iol]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1iol]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IOL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IOL FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1iol]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IOL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IOL FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EST:ESTRADIOL'>EST</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/17-beta-estradiol_17-dehydrogenase 17-beta-estradiol 17-dehydrogenase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.62 1.1.1.62] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EST:ESTRADIOL'>EST</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1iol FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1iol OCA], [https://pdbe.org/1iol PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1iol RCSB], [https://www.ebi.ac.uk/pdbsum/1iol PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1iol ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1iol FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1iol OCA], [https://pdbe.org/1iol PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1iol RCSB], [https://www.ebi.ac.uk/pdbsum/1iol PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1iol ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/DHB1_HUMAN DHB1_HUMAN]] Favors the reduction of estrogens and androgens. Also has 20-alpha-HSD activity. Uses preferentially NADH.
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[https://www.uniprot.org/uniprot/DHB1_HUMAN DHB1_HUMAN] Favors the reduction of estrogens and androgens. Also has 20-alpha-HSD activity. Uses preferentially NADH.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: 17-beta-estradiol 17-dehydrogenase]]
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[[Category: Homo sapiens]]
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[[Category: Human]]
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[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Azzi, A]]
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[[Category: Azzi A]]
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[[Category: Campbell, R L]]
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[[Category: Campbell RL]]
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[[Category: Labrie, F]]
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[[Category: Labrie F]]
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[[Category: Lin, S X]]
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[[Category: Lin S-X]]
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[[Category: Rehse, P H]]
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[[Category: Rehse PH]]
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[[Category: Zhu, D W]]
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[[Category: Zhu D-W]]
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[[Category: Oxidoreductase]]
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[[Category: Short-chain dehydrogenase]]
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[[Category: Steroid biosynthesis]]
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Current revision

ESTROGENIC 17-BETA HYDROXYSTEROID DEHYDROGENASE COMPLEXED 17-BETA-ESTRADIOL

PDB ID 1iol

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