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1prq

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==ACANTHAMOEBA CASTELLANII PROFILIN IA==
==ACANTHAMOEBA CASTELLANII PROFILIN IA==
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<StructureSection load='1prq' size='340' side='right' caption='[[1prq]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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<StructureSection load='1prq' size='340' side='right'caption='[[1prq]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1prq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Acaca Acaca]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PRQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PRQ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1prq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Acanthamoeba_castellanii Acanthamoeba castellanii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PRQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PRQ FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1prq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1prq OCA], [http://pdbe.org/1prq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1prq RCSB], [http://www.ebi.ac.uk/pdbsum/1prq PDBsum]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1prq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1prq OCA], [https://pdbe.org/1prq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1prq RCSB], [https://www.ebi.ac.uk/pdbsum/1prq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1prq ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PRO1A_ACACA PRO1A_ACACA]] Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG.
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[https://www.uniprot.org/uniprot/PRO1A_ACACA PRO1A_ACACA] Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pr/1prq_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pr/1prq_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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==See Also==
==See Also==
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*[[Profilin|Profilin]]
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*[[Profilin 3D Structures|Profilin 3D Structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Acaca]]
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[[Category: Acanthamoeba castellanii]]
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[[Category: Almo, S C]]
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[[Category: Large Structures]]
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[[Category: Fedorov, A A]]
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[[Category: Almo SC]]
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[[Category: Lattman, E E]]
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[[Category: Fedorov AA]]
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[[Category: Pollard, T D]]
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[[Category: Lattman EE]]
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[[Category: Way, M]]
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[[Category: Pollard TD]]
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[[Category: Actin-binding protein]]
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[[Category: Way M]]
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[[Category: Contractile protein]]
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Current revision

ACANTHAMOEBA CASTELLANII PROFILIN IA

PDB ID 1prq

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