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1sgf

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<StructureSection load='1sgf' size='340' side='right'caption='[[1sgf]], [[Resolution|resolution]] 3.15&Aring;' scene=''>
<StructureSection load='1sgf' size='340' side='right'caption='[[1sgf]], [[Resolution|resolution]] 3.15&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1sgf]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SGF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1SGF FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1sgf]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SGF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SGF FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.15&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tissue_kallikrein Tissue kallikrein], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.35 3.4.21.35] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1sgf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sgf OCA], [http://pdbe.org/1sgf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1sgf RCSB], [http://www.ebi.ac.uk/pdbsum/1sgf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1sgf ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1sgf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sgf OCA], [https://pdbe.org/1sgf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1sgf RCSB], [https://www.ebi.ac.uk/pdbsum/1sgf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1sgf ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/K1KB3_MOUSE K1KB3_MOUSE]] 7S NGF alpha chain stabilizes the 7S complex. The beta dimer promotes neurite growth. The gamma chain is an arginine-specific protease; it may also have plasminogen activator activity, as well as mitogenic activity for chick embryo fibroblasts. [[http://www.uniprot.org/uniprot/NGF_MOUSE NGF_MOUSE]] Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival.
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[https://www.uniprot.org/uniprot/K1KB4_MOUSE K1KB4_MOUSE]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</div>
</div>
<div class="pdbe-citations 1sgf" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 1sgf" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Nerve growth factor|Nerve growth factor]]
== References ==
== References ==
<references/>
<references/>
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[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Tissue kallikrein]]
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[[Category: Bax BDV]]
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[[Category: Bax, B D.V]]
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[[Category: Blundell TL]]
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[[Category: Blundell, T L]]
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[[Category: Mcdonald NQ]]
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[[Category: Mcdonald, N Q]]
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[[Category: Murray-Rust J]]
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[[Category: Murray-Rust, J]]
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[[Category: Growth factor]]
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Current revision

CRYSTAL STRUCTURE OF 7S NGF: A COMPLEX OF NERVE GROWTH FACTOR WITH FOUR BINDING PROTEINS (SERINE PROTEINASES)

PDB ID 1sgf

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