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2bct

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==THE ARMADILLO REPEAT REGION FROM MURINE BETA-CATENIN==
==THE ARMADILLO REPEAT REGION FROM MURINE BETA-CATENIN==
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<StructureSection load='2bct' size='340' side='right' caption='[[2bct]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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<StructureSection load='2bct' size='340' side='right'caption='[[2bct]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2bct]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BCT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BCT FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2bct]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BCT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BCT FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bct FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bct OCA], [http://pdbe.org/2bct PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2bct RCSB], [http://www.ebi.ac.uk/pdbsum/2bct PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2bct ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bct FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bct OCA], [https://pdbe.org/2bct PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bct RCSB], [https://www.ebi.ac.uk/pdbsum/2bct PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bct ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CTNB1_MOUSE CTNB1_MOUSE]] Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2 (By similarity).
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[https://www.uniprot.org/uniprot/CTNB1_MOUSE CTNB1_MOUSE] Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2 (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
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*[[Catenin|Catenin]]
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*[[Catenin 3D structures|Catenin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Lk3 transgenic mice]]
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[[Category: Large Structures]]
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[[Category: Huber, A H]]
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[[Category: Mus musculus]]
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[[Category: Nelson, W J]]
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[[Category: Huber AH]]
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[[Category: Weis, W I]]
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[[Category: Nelson WJ]]
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[[Category: Armadillo repeat]]
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[[Category: Weis WI]]
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[[Category: Beta-catenin]]
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[[Category: Structural protein]]
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Current revision

THE ARMADILLO REPEAT REGION FROM MURINE BETA-CATENIN

PDB ID 2bct

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