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5h4z

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(New page: ==Crystal structure of S202G mutant of human SYT-5 C2A domain== <StructureSection load='5h4z' size='340' side='right' caption='5h4z, resolution 3.01&Aring;' scene=''> =...)
Current revision (07:23, 9 August 2023) (edit) (undo)
 
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==Crystal structure of S202G mutant of human SYT-5 C2A domain==
==Crystal structure of S202G mutant of human SYT-5 C2A domain==
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<StructureSection load='5h4z' size='340' side='right' caption='[[5h4z]], [[Resolution|resolution]] 3.01&Aring;' scene=''>
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<StructureSection load='5h4z' size='340' side='right'caption='[[5h4z]], [[Resolution|resolution]] 3.01&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5h4z]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5H4Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5H4Z FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5h4z]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5H4Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5H4Z FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.01&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5h4y|5h4y]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5h4z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5h4z OCA], [http://pdbe.org/5h4z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5h4z RCSB], [http://www.ebi.ac.uk/pdbsum/5h4z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5h4z ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5h4z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5h4z OCA], [https://pdbe.org/5h4z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5h4z RCSB], [https://www.ebi.ac.uk/pdbsum/5h4z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5h4z ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/SYT5_HUMAN SYT5_HUMAN]] May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Regulates the Ca(2+)-dependent secretion of norepinephrine in PC12 cells. Required for export from the endocytic recycling compartment to the cell surface (By similarity).
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[https://www.uniprot.org/uniprot/SYT5_HUMAN SYT5_HUMAN] May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Regulates the Ca(2+)-dependent secretion of norepinephrine in PC12 cells. Required for export from the endocytic recycling compartment to the cell surface (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5h4z" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5h4z" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Synaptotagmin 3D structures|Synaptotagmin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Gao, Y]]
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[[Category: Homo sapiens]]
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[[Category: Ge, J]]
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[[Category: Large Structures]]
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[[Category: Niu, L]]
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[[Category: Gao Y]]
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[[Category: Qiu, X]]
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[[Category: Ge J]]
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[[Category: Teng, M]]
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[[Category: Niu L]]
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[[Category: Yan, X]]
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[[Category: Qiu X]]
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[[Category: Metal binding protein]]
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[[Category: Teng M]]
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[[Category: Mutant]]
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[[Category: Yan X]]

Current revision

Crystal structure of S202G mutant of human SYT-5 C2A domain

PDB ID 5h4z

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