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5hd6

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Current revision (07:31, 9 August 2023) (edit) (undo)
 
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<StructureSection load='5hd6' size='340' side='right'caption='[[5hd6]], [[Resolution|resolution]] 1.35&Aring;' scene=''>
<StructureSection load='5hd6' size='340' side='right'caption='[[5hd6]], [[Resolution|resolution]] 1.35&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5hd6]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Yersinia_pestis_co92 Yersinia pestis co92]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HD6 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5HD6 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5hd6]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Yersinia_pestis_CO92 Yersinia pestis CO92]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HD6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5HD6 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.35&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">fabA, AK38_1122 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=214092 Yersinia pestis CO92])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5hd6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hd6 OCA], [https://pdbe.org/5hd6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5hd6 RCSB], [https://www.ebi.ac.uk/pdbsum/5hd6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5hd6 ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3-hydroxyacyl-[acyl-carrier-protein]_dehydratase 3-hydroxyacyl-[acyl-carrier-protein] dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.59 4.2.1.59] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5hd6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hd6 OCA], [http://pdbe.org/5hd6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hd6 RCSB], [http://www.ebi.ac.uk/pdbsum/5hd6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5hd6 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/A0A0B6NZG1_YERPE A0A0B6NZG1_YERPE]] Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP. Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length (By similarity).[SAAS:SAAS00370957]
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[https://www.uniprot.org/uniprot/FABA_YERPE FABA_YERPE] Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP. Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length.[HAMAP-Rule:MF_00405]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Yersinia pestis co92]]
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[[Category: Yersinia pestis CO92]]
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[[Category: Anderson, W F]]
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[[Category: Anderson WF]]
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[[Category: Structural genomic]]
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[[Category: Chang C]]
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[[Category: Chang, C]]
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[[Category: Joachimiak A]]
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[[Category: Joachimiak, A]]
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[[Category: Kim Y]]
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[[Category: Kim, Y]]
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[[Category: Kwon K]]
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[[Category: Kwon, K]]
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[[Category: Maltseva N]]
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[[Category: Maltseva, N]]
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[[Category: Mulligan R]]
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[[Category: Mulligan, R]]
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[[Category: Csgid]]
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[[Category: Lyase]]
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[[Category: Mcsg]]
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[[Category: Psi-biology]]
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Current revision

High resolution structure of 3-hydroxydecanoyl-(acyl carrier protein) dehydratase from Yersinia pestis at 1.35 A

PDB ID 5hd6

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