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5hem
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==Crystal structure of the N-terminus D161Y bromodomain mutant of human BRD2== | ==Crystal structure of the N-terminus D161Y bromodomain mutant of human BRD2== | ||
| - | <StructureSection load='5hem' size='340' side='right' caption='[[5hem]], [[Resolution|resolution]] 1.65Å' scene=''> | + | <StructureSection load='5hem' size='340' side='right'caption='[[5hem]], [[Resolution|resolution]] 1.65Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5hem]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HEM OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[5hem]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HEM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5HEM FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65Å</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5hem FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hem OCA], [https://pdbe.org/5hem PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5hem RCSB], [https://www.ebi.ac.uk/pdbsum/5hem PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5hem ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/BRD2_HUMAN BRD2_HUMAN] May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly.<ref>PMID:18406326</ref> |
| + | |||
| + | ==See Also== | ||
| + | *[[Bromodomain-containing protein 3D structures|Bromodomain-containing protein 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Arrowsmith | + | [[Category: Homo sapiens]] |
| - | [[Category: Bountra | + | [[Category: Large Structures]] |
| - | [[Category: Chiaraluce | + | [[Category: Arrowsmith CH]] |
| - | [[Category: Consalvi | + | [[Category: Bountra C]] |
| - | + | [[Category: Chiaraluce R]] | |
| - | [[Category: Edwards | + | [[Category: Consalvi V]] |
| - | [[Category: Knapp | + | [[Category: Edwards AM]] |
| - | [[Category: Lori | + | [[Category: Knapp S]] |
| - | [[Category: Newman | + | [[Category: Lori C]] |
| - | [[Category: Pasquo | + | [[Category: Newman JA]] |
| - | [[Category: Tallant | + | [[Category: Pasquo A]] |
| - | [[Category: | + | [[Category: Tallant C]] |
| - | + | [[Category: Von Delft F]] | |
| - | + | ||
Current revision
Crystal structure of the N-terminus D161Y bromodomain mutant of human BRD2
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Categories: Homo sapiens | Large Structures | Arrowsmith CH | Bountra C | Chiaraluce R | Consalvi V | Edwards AM | Knapp S | Lori C | Newman JA | Pasquo A | Tallant C | Von Delft F
