5hi6

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m (Protected "5hi6" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 5hi6 is ON HOLD
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==The high resolution structure of dihydrofolate reductase from Yersinia pestis complex with methotrexate as closed form==
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<StructureSection load='5hi6' size='340' side='right'caption='[[5hi6]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5hi6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Yersinia_pestis_CO92 Yersinia pestis CO92]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HI6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5HI6 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.051&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=MTX:METHOTREXATE'>MTX</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5hi6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hi6 OCA], [https://pdbe.org/5hi6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5hi6 RCSB], [https://www.ebi.ac.uk/pdbsum/5hi6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5hi6 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/A0A3N4BLI0_YERPE A0A3N4BLI0_YERPE] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.[ARBA:ARBA00025067][PIRNR:PIRNR000194]
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Authors: Chang, C., Maltseva, N., Kim, Y., Makowska-Grzyska, M., Mulligan, R., Papazisi, L., Anderson, W.F., Joachimiak, A., Center for Structural Genomics of Infectious Diseases (CSGID)
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==See Also==
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*[[Dihydrofolate reductase 3D structures|Dihydrofolate reductase 3D structures]]
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Description: The high resolution structure of dihydrofolate reductase from Yersinia pestis complex with methotrxate as closed form
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__TOC__
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[[Category: Unreleased Structures]]
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</StructureSection>
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[[Category: Joachimiak, A]]
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[[Category: Large Structures]]
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[[Category: Papazisi, L]]
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[[Category: Yersinia pestis CO92]]
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[[Category: Mulligan, R]]
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[[Category: Anderson WF]]
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[[Category: Makowska-Grzyska, M]]
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[[Category: Chang C]]
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[[Category: Maltseva, N]]
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[[Category: Joachimiak A]]
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[[Category: Anderson, W.F]]
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[[Category: Kim Y]]
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[[Category: Center For Structural Genomics Of Infectious Diseases (Csgid)]]
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[[Category: Makowska-Grzyska M]]
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[[Category: Kim, Y]]
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[[Category: Maltseva N]]
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[[Category: Chang, C]]
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[[Category: Mulligan R]]
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[[Category: Papazisi L]]

Current revision

The high resolution structure of dihydrofolate reductase from Yersinia pestis complex with methotrexate as closed form

PDB ID 5hi6

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