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1jbr

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==Crystal Structure of the Ribotoxin Restrictocin and a 31-mer SRD RNA Inhibitor==
==Crystal Structure of the Ribotoxin Restrictocin and a 31-mer SRD RNA Inhibitor==
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<StructureSection load='1jbr' size='340' side='right' caption='[[1jbr]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
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<StructureSection load='1jbr' size='340' side='right'caption='[[1jbr]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1jbr]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Aspre Aspre]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JBR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JBR FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1jbr]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Aspergillus_restrictus Aspergillus restrictus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JBR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JBR FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=A23:ADENOSINE-5-PHOSPHATE-2,3-CYCLIC+PHOSPHATE'>A23</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A23:ADENOSINE-5-PHOSPHATE-2,3-CYCLIC+PHOSPHATE'>A23</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1aqz|1aqz]], [[430d|430d]], [[480d|480d]], [[483d|483d]], [[1jbs|1jbs]], [[1jbt|1jbt]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jbr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jbr OCA], [https://pdbe.org/1jbr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jbr RCSB], [https://www.ebi.ac.uk/pdbsum/1jbr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jbr ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jbr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jbr OCA], [http://pdbe.org/1jbr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1jbr RCSB], [http://www.ebi.ac.uk/pdbsum/1jbr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1jbr ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/RNMG_ASPRE RNMG_ASPRE]] This purine-specific ribonuclease cleaves 28S RNA in eukaryotic ribosomes, inhibits protein synthesis, and shows antitumor activity.
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[https://www.uniprot.org/uniprot/RNMG_ASPRE RNMG_ASPRE] This purine-specific ribonuclease cleaves 28S RNA in eukaryotic ribosomes, inhibits protein synthesis, and shows antitumor activity.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jb/1jbr_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jb/1jbr_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Aspre]]
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[[Category: Aspergillus restrictus]]
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[[Category: Correll, C C]]
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[[Category: Large Structures]]
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[[Category: Gerczei, T]]
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[[Category: Correll CC]]
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[[Category: Glover, L]]
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[[Category: Gerczei T]]
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[[Category: Yang, X]]
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[[Category: Glover L]]
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[[Category: Base flipping]]
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[[Category: Yang X]]
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[[Category: Hydrolase-rna complex]]
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[[Category: Protein-rna interaction]]
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[[Category: Restrictocin]]
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[[Category: Ribosomal rna]]
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[[Category: Sarcin/ricin domain]]
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[[Category: Specific recognition]]
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Current revision

Crystal Structure of the Ribotoxin Restrictocin and a 31-mer SRD RNA Inhibitor

PDB ID 1jbr

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