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1juf

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==Structure of Minor Histocompatibility Antigen peptide, H13b, complexed to H2-Db==
==Structure of Minor Histocompatibility Antigen peptide, H13b, complexed to H2-Db==
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<StructureSection load='1juf' size='340' side='right' caption='[[1juf]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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<StructureSection load='1juf' size='340' side='right'caption='[[1juf]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1juf]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JUF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JUF FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1juf]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JUF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JUF FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1inq|1inq]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">H2-D ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), beta-2-microglobulin ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1juf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1juf OCA], [https://pdbe.org/1juf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1juf RCSB], [https://www.ebi.ac.uk/pdbsum/1juf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1juf ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1juf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1juf OCA], [http://pdbe.org/1juf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1juf RCSB], [http://www.ebi.ac.uk/pdbsum/1juf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1juf ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/HA11_MOUSE HA11_MOUSE]] Involved in the presentation of foreign antigens to the immune system. [[http://www.uniprot.org/uniprot/HM13_MOUSE HM13_MOUSE]] Catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein, resulting in the release of the fragment from the ER membrane into the cytoplasm. Required to generate lymphocyte cell surface (HLA-E) epitopes derived from MHC class I signal peptides. Involved in the intramembrane cleavage of the integral membrane protein PSEN1 (By similarity). May play a role in graft rejection. [[http://www.uniprot.org/uniprot/B2MG_MOUSE B2MG_MOUSE]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
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[https://www.uniprot.org/uniprot/HA11_MOUSE HA11_MOUSE] Involved in the presentation of foreign antigens to the immune system.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
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*[[Beta-2 microglobulin|Beta-2 microglobulin]]
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*[[Beta-2 microglobulin 3D structures|Beta-2 microglobulin 3D structures]]
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*[[Major histocompatibility complex|Major histocompatibility complex]]
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*[[MHC 3D structures|MHC 3D structures]]
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*[[MHC I 3D structures|MHC I 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Lk3 transgenic mice]]
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[[Category: Large Structures]]
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[[Category: Almo, S C]]
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[[Category: Mus musculus]]
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[[Category: Christianson, G J]]
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[[Category: Almo SC]]
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[[Category: Grey, H]]
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[[Category: Christianson GJ]]
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[[Category: Mendoza, L]]
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[[Category: Grey H]]
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[[Category: Nathenson, S G]]
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[[Category: Mendoza L]]
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[[Category: Ostrov, D A]]
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[[Category: Nathenson SG]]
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[[Category: Palmieri, E]]
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[[Category: Ostrov DA]]
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[[Category: Roden, M M]]
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[[Category: Palmieri E]]
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[[Category: Roopenian, D C]]
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[[Category: Roden MM]]
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[[Category: Shastri, N]]
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[[Category: Roopenian DC]]
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[[Category: Shi, W]]
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[[Category: Shastri N]]
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[[Category: Tilley, D]]
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[[Category: Shi W]]
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[[Category: Villaflor, G]]
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[[Category: Tilley D]]
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[[Category: H13]]
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[[Category: Villaflor G]]
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[[Category: H2-db]]
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[[Category: Immune system]]
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[[Category: Mhc class-i]]
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[[Category: Minor histocompatibility antigen]]
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Current revision

Structure of Minor Histocompatibility Antigen peptide, H13b, complexed to H2-Db

PDB ID 1juf

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