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1k6u

From Proteopedia

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[[Image:1k6u.png|left|200px]]
 
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{{STRUCTURE_1k6u| PDB=1k6u | SCENE= }}
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==Crystal Structure of Cyclic Bovine Pancreatic Trypsin Inhibitor==
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<StructureSection load='1k6u' size='340' side='right'caption='[[1k6u]], [[Resolution|resolution]] 1.00&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1k6u]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K6U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1K6U FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1k6u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k6u OCA], [https://pdbe.org/1k6u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1k6u RCSB], [https://www.ebi.ac.uk/pdbsum/1k6u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1k6u ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/BPT1_BOVIN BPT1_BOVIN] Inhibits trypsin, kallikrein, chymotrypsin, and plasmin.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k6/1k6u_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1k6u ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The crystal structure of a cyclic form of a mutant of bovine pancreatic trypsin inhibitor has been solved at 1.0 A resolution. The protein was synthesized by native chemical ligation and its structure is almost indistinguishable from the previously described recombinant form of the same mutant; however, the new loop containing the former termini became much better ordered.
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===Crystal Structure of Cyclic Bovine Pancreatic Trypsin Inhibitor===
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Crystal structure of a cyclic form of bovine pancreatic trypsin inhibitor.,Botos I, Wu Z, Lu W, Wlodawer A FEBS Lett. 2001 Nov 30;509(1):90-4. PMID:11734212<ref>PMID:11734212</ref>
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{{ABSTRACT_PUBMED_11734212}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 1k6u" style="background-color:#fffaf0;"></div>
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[[1k6u]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K6U OCA].
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==See Also==
==See Also==
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*[[Basic Pancreatic Trypsin Inhibitor|Basic Pancreatic Trypsin Inhibitor]]
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*[[BPTI 3D structures|BPTI 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:011734212</ref><ref group="xtra">PMID:018754631</ref><references group="xtra"/>
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__TOC__
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[[Category: Botos, I.]]
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</StructureSection>
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[[Category: Lu, W.]]
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[[Category: Bos taurus]]
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[[Category: Wlodawer, A.]]
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[[Category: Large Structures]]
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[[Category: Wu, Z.]]
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[[Category: Botos I]]
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[[Category: Atomic resolution]]
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[[Category: Lu W]]
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[[Category: Bpti]]
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[[Category: Wlodawer A]]
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[[Category: Cyclic protein]]
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[[Category: Wu Z]]
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[[Category: Hydrolase inhibitor]]
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Current revision

Crystal Structure of Cyclic Bovine Pancreatic Trypsin Inhibitor

PDB ID 1k6u

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