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1kn3

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{{Seed}}
 
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[[Image:1kn3.png|left|200px]]
 
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==Murine PEBP-2 (phosphatidylethanolamine-binding protein-2)==
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The line below this paragraph, containing "STRUCTURE_1kn3", creates the "Structure Box" on the page.
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<StructureSection load='1kn3' size='340' side='right'caption='[[1kn3]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1kn3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KN3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KN3 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kn3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kn3 OCA], [https://pdbe.org/1kn3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kn3 RCSB], [https://www.ebi.ac.uk/pdbsum/1kn3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kn3 ProSAT]</span></td></tr>
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{{STRUCTURE_1kn3| PDB=1kn3 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PEBP2_MOUSE PEBP2_MOUSE] May bind to phospholipids. May act as serine protease inhibitor (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kn/1kn3_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1kn3 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Proteins from the PEBP (phosphatidylethanolamine-binding protein) family have been identified in a wide variety of species and are thought to regulate a range of intracellular signalling cascades. The rat homologue (known as RKIP; Raf-1 kinase inhibitor protein) has been shown to negatively regulate the MAP kinase pathway through formation of inhibitory complexes with Raf-1 and MEK. The crystal structure of a new, murine member of the PEBP family, termed mPEBP-2, has been determined. On the basis of amino-acid homology, mPEBP-2 belongs to a distinct subset of the mammalian PEBP proteins. Nonetheless, mPEBP-2 is seen to be very similar in structure to other PEBP proteins from human, bovine and plant sources. Regions of distinctive sequence associated with the PEBP-2 subset are discussed with reference to this structure.
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===Murine PEBP-2 (phosphatidylethanolamine-binding protein-2)===
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The crystal structure of PEBP-2, a homologue of the PEBP/RKIP family.,Simister PC, Banfield MJ, Brady RL Acta Crystallogr D Biol Crystallogr. 2002 Jun;58(Pt 6 Pt 2):1077-80. Epub, 2002 May 29. PMID:12037323<ref>PMID:12037323</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_12037323}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1kn3" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 12037323 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_12037323}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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1KN3 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KN3 OCA].
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==Reference==
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The crystal structure of PEBP-2, a homologue of the PEBP/RKIP family., Simister PC, Banfield MJ, Brady RL, Acta Crystallogr D Biol Crystallogr. 2002 Jun;58(Pt 6 Pt 2):1077-80. Epub, 2002 May 29. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12037323 12037323]
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[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Single protein]]
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[[Category: Banfield MJ]]
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[[Category: Banfield, M J.]]
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[[Category: Brady RL]]
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[[Category: Brady, R L.]]
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[[Category: Simister PC]]
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[[Category: Simister, P C.]]
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[[Category: Cis-peptide]]
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[[Category: Phosphatidylethanolamine binding]]
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[[Category: Raf-1 kinase inhibitor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 10:34:54 2008''
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Current revision

Murine PEBP-2 (phosphatidylethanolamine-binding protein-2)

PDB ID 1kn3

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