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1kqu

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==Human phospholipase A2 complexed with a substrate anologue==
==Human phospholipase A2 complexed with a substrate anologue==
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<StructureSection load='1kqu' size='340' side='right' caption='[[1kqu]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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<StructureSection load='1kqu' size='340' side='right'caption='[[1kqu]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1kqu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KQU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KQU FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1kqu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KQU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KQU FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BR4:6-PHENYL-4(R)-(7-PHENYL-HEPTANOYLAMINO)-HEXANOIC+ACID'>BR4</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1d4k|1d4k]], [[1d4l|1d4l]], [[1kqt|1kqt]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BR4:6-PHENYL-4(R)-(7-PHENYL-HEPTANOYLAMINO)-HEXANOIC+ACID'>BR4</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kqu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kqu OCA], [https://pdbe.org/1kqu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kqu RCSB], [https://www.ebi.ac.uk/pdbsum/1kqu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kqu ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kqu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kqu OCA], [http://pdbe.org/1kqu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1kqu RCSB], [http://www.ebi.ac.uk/pdbsum/1kqu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1kqu ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PA2GA_HUMAN PA2GA_HUMAN]] Thought to participate in the regulation of the phospholipid metabolism in biomembranes including eicosanoid biosynthesis. Catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
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[https://www.uniprot.org/uniprot/PA2GA_HUMAN PA2GA_HUMAN] Thought to participate in the regulation of the phospholipid metabolism in biomembranes including eicosanoid biosynthesis. Catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</div>
</div>
<div class="pdbe-citations 1kqu" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 1kqu" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Phospholipase A2 3D structures|Phospholipase A2 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Martin, J L]]
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[[Category: Large Structures]]
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[[Category: Tyndall, J D]]
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[[Category: Martin JL]]
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[[Category: Hydrolase]]
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[[Category: Tyndall JD]]
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[[Category: Inhibitor]]
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[[Category: Phospholipase a2]]
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Current revision

Human phospholipase A2 complexed with a substrate anologue

PDB ID 1kqu

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