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1l2g

From Proteopedia

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{{Seed}}
 
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[[Image:1l2g.png|left|200px]]
 
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==Structure of a C-terminally truncated form of glycoprotein D from HSV-1==
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The line below this paragraph, containing "STRUCTURE_1l2g", creates the "Structure Box" on the page.
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<StructureSection load='1l2g' size='340' side='right'caption='[[1l2g]], [[Resolution|resolution]] 2.85&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1l2g]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_alphaherpesvirus_1 Human alphaherpesvirus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L2G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1L2G FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.85&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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{{STRUCTURE_1l2g| PDB=1l2g | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1l2g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l2g OCA], [https://pdbe.org/1l2g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1l2g RCSB], [https://www.ebi.ac.uk/pdbsum/1l2g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1l2g ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GD_HHV1P GD_HHV1P] Envelope glycoprotein that binds to the potential host cell entry receptors TNFRSF14/HVEM, PVRL1 and 3-O-sulfated heparan sulfate. May trigger fusion with host membrane, by recruiting the fusion machinery composed of gB and gH/gL (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l2/1l2g_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1l2g ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Herpes simplex virus (HSV) infection requires binding of the viral envelope glycoprotein D (gD) to cell surface receptors. We report the X-ray structures of a soluble, truncated ectodomain of gD both alone and in complex with the ectodomain of its cellular receptor HveA. Two bound anions suggest possible binding sites for another gD receptor, a 3-O-sulfonated heparan sulfate. Unexpectedly, the structures reveal a V-like immunoglobulin (Ig) fold at the core of gD that is closely related to cellular adhesion molecules and flanked by large N- and C-terminal extensions. The receptor binding segment of gD, an N-terminal hairpin, appears conformationally flexible, suggesting that a conformational change accompanying binding might be part of the viral entry mechanism.
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===Structure of a C-terminally truncated form of glycoprotein D from HSV-1===
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Herpes simplex virus glycoprotein D bound to the human receptor HveA.,Carfi A, Willis SH, Whitbeck JC, Krummenacher C, Cohen GH, Eisenberg RJ, Wiley DC Mol Cell. 2001 Jul;8(1):169-79. PMID:11511370<ref>PMID:11511370</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1l2g" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_11511370}}, adds the Publication Abstract to the page
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*[[Glycoproteins B and D|Glycoproteins B and D]]
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(as it appears on PubMed at http://www.pubmed.gov), where 11511370 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_11511370}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Human alphaherpesvirus 1]]
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1L2G is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_herpesvirus_1 Human herpesvirus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L2G OCA].
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[[Category: Large Structures]]
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[[Category: Carfi A]]
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==Reference==
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[[Category: Cohen GH]]
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Herpes simplex virus glycoprotein D bound to the human receptor HveA., Carfi A, Willis SH, Whitbeck JC, Krummenacher C, Cohen GH, Eisenberg RJ, Wiley DC, Mol Cell. 2001 Jul;8(1):169-79. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11511370 11511370]
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[[Category: Eisenberg RJ]]
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[[Category: Human herpesvirus 1]]
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[[Category: Krummenacher C]]
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[[Category: Single protein]]
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[[Category: Whitbeck JC]]
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[[Category: Carfi, A.]]
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[[Category: Wiley DC]]
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[[Category: Cohen, G H.]]
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[[Category: Willis SH]]
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[[Category: Eisenberg, R J.]]
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[[Category: Krummenacher, C.]]
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[[Category: Whitbeck, J C.]]
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[[Category: Wiley, D C.]]
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[[Category: Willis, S H.]]
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[[Category: Ig fold]]
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[[Category: Viral envelope glycoprotein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 11:32:55 2008''
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Current revision

Structure of a C-terminally truncated form of glycoprotein D from HSV-1

PDB ID 1l2g

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