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1nme

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Current revision (09:22, 16 August 2023) (edit) (undo)
 
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<StructureSection load='1nme' size='340' side='right'caption='[[1nme]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
<StructureSection load='1nme' size='340' side='right'caption='[[1nme]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1nme]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NME OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NME FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1nme]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NME OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NME FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=158:3-(2-MERCAPTO-ACETYLAMINO)-4-OXO-PENTANOIC+ACID'>158</scene>, <scene name='pdbligand=159:2-HYDROXY-5-(2-MERCAPTO-ETHYLSULFAMOYL)-BENZOIC+ACID'>159</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1nmq|1nmq]], [[1nms|1nms]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=158:3-(2-MERCAPTO-ACETYLAMINO)-4-OXO-PENTANOIC+ACID'>158</scene>, <scene name='pdbligand=159:2-HYDROXY-5-(2-MERCAPTO-ETHYLSULFAMOYL)-BENZOIC+ACID'>159</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nme FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nme OCA], [https://pdbe.org/1nme PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nme RCSB], [https://www.ebi.ac.uk/pdbsum/1nme PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nme ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nme FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nme OCA], [https://pdbe.org/1nme PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nme RCSB], [https://www.ebi.ac.uk/pdbsum/1nme PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nme ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/CASP3_HUMAN CASP3_HUMAN]] Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.<ref>PMID:7596430</ref> <ref>PMID:21357690</ref>
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[https://www.uniprot.org/uniprot/CASP3_HUMAN CASP3_HUMAN] Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.<ref>PMID:7596430</ref> <ref>PMID:21357690</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Brian, T O]]
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[[Category: Choong IC]]
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[[Category: Choong, I C]]
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[[Category: DeLano W]]
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[[Category: DeLano, W]]
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[[Category: Erlanson DA]]
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[[Category: Erlanson, D A]]
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[[Category: Flanagan M]]
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[[Category: Flanagan, M]]
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[[Category: Lam J]]
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[[Category: Lam, J]]
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[[Category: Lee D]]
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[[Category: Lee, D]]
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[[Category: Luong TN]]
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[[Category: Luong, T N]]
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[[Category: O'Brian T]]
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[[Category: Simmons, B]]
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[[Category: Simmons B]]
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[[Category: Wiesmann, C]]
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[[Category: Wiesmann C]]
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[[Category: Apoptosis]]
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[[Category: Cysteine proteinase]]
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[[Category: Hydrolase]]
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[[Category: Sulfonamide inhibition]]
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Current revision

Structure of Casp-3 with tethered salicylate

PDB ID 1nme

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OCA

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