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1npz

From Proteopedia

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==Crystal structures of Cathepsin S inhibitor complexes==
==Crystal structures of Cathepsin S inhibitor complexes==
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<StructureSection load='1npz' size='340' side='right' caption='[[1npz]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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<StructureSection load='1npz' size='340' side='right'caption='[[1npz]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1npz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NPZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NPZ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1npz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NPZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NPZ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C1P:N~2~-(MORPHOLIN-4-YLCARBONYL)-N-[(3S)-1-PHENYL-5-(PHENYLSULFONYL)PENTAN-3-YL]-L-LEUCINAMIDE'>C1P</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1nqc|1nqc]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C1P:N~2~-(MORPHOLIN-4-YLCARBONYL)-N-[(3S)-1-PHENYL-5-(PHENYLSULFONYL)PENTAN-3-YL]-L-LEUCINAMIDE'>C1P</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cathepsin_S Cathepsin S], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.27 3.4.22.27] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1npz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1npz OCA], [https://pdbe.org/1npz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1npz RCSB], [https://www.ebi.ac.uk/pdbsum/1npz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1npz ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1npz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1npz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1npz RCSB], [http://www.ebi.ac.uk/pdbsum/1npz PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CATS_HUMAN CATS_HUMAN]] Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N.
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[https://www.uniprot.org/uniprot/CATS_HUMAN CATS_HUMAN] Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/np/1npz_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/np/1npz_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1npz ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 1npz" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[Cathepsin|Cathepsin]]
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*[[Cathepsin 3D structures|Cathepsin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Cathepsin S]]
 
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Ammirati, M]]
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[[Category: Large Structures]]
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[[Category: Cygler, M]]
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[[Category: Ammirati M]]
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[[Category: Danley, D E]]
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[[Category: Cygler M]]
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[[Category: Griffor, M C]]
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[[Category: Danley DE]]
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[[Category: Kamath, A V]]
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[[Category: Griffor MC]]
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[[Category: Laird, E R]]
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[[Category: Kamath AV]]
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[[Category: Menard, R]]
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[[Category: Laird ER]]
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[[Category: Pauly, T A]]
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[[Category: Menard R]]
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[[Category: Rath, V L]]
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[[Category: Pauly TA]]
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[[Category: Seddon, A P]]
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[[Category: Rath VL]]
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[[Category: Sivaraman, J]]
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[[Category: Seddon AP]]
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[[Category: Sulea, T]]
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[[Category: Sivaraman J]]
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[[Category: Wang, I K]]
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[[Category: Sulea T]]
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[[Category: Antigen presentation]]
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[[Category: Wang IK]]
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[[Category: Binding specificity]]
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[[Category: Cysteine protease]]
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[[Category: Hydrolase]]
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[[Category: Inhibitor complex]]
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[[Category: Structural plasticity]]
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[[Category: Structure-based design]]
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Current revision

Crystal structures of Cathepsin S inhibitor complexes

PDB ID 1npz

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