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1npz
From Proteopedia
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==Crystal structures of Cathepsin S inhibitor complexes== | ==Crystal structures of Cathepsin S inhibitor complexes== | ||
| - | <StructureSection load='1npz' size='340' side='right' caption='[[1npz]], [[Resolution|resolution]] 2.00Å' scene=''> | + | <StructureSection load='1npz' size='340' side='right'caption='[[1npz]], [[Resolution|resolution]] 2.00Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1npz]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[1npz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NPZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NPZ FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C1P:N~2~-(MORPHOLIN-4-YLCARBONYL)-N-[(3S)-1-PHENYL-5-(PHENYLSULFONYL)PENTAN-3-YL]-L-LEUCINAMIDE'>C1P</scene></td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1npz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1npz OCA], [https://pdbe.org/1npz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1npz RCSB], [https://www.ebi.ac.uk/pdbsum/1npz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1npz ProSAT]</span></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/CATS_HUMAN CATS_HUMAN] Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N. |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/np/1npz_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/np/1npz_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
| - | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1npz ConSurf]. |
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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==See Also== | ==See Also== | ||
| - | *[[Cathepsin|Cathepsin]] | + | *[[Cathepsin 3D structures|Cathepsin 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Cathepsin S]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Ammirati | + | [[Category: Large Structures]] |
| - | [[Category: Cygler | + | [[Category: Ammirati M]] |
| - | [[Category: Danley | + | [[Category: Cygler M]] |
| - | [[Category: Griffor | + | [[Category: Danley DE]] |
| - | [[Category: Kamath | + | [[Category: Griffor MC]] |
| - | [[Category: Laird | + | [[Category: Kamath AV]] |
| - | [[Category: Menard | + | [[Category: Laird ER]] |
| - | [[Category: Pauly | + | [[Category: Menard R]] |
| - | [[Category: Rath | + | [[Category: Pauly TA]] |
| - | [[Category: Seddon | + | [[Category: Rath VL]] |
| - | [[Category: Sivaraman | + | [[Category: Seddon AP]] |
| - | [[Category: Sulea | + | [[Category: Sivaraman J]] |
| - | [[Category: Wang | + | [[Category: Sulea T]] |
| - | + | [[Category: Wang IK]] | |
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Current revision
Crystal structures of Cathepsin S inhibitor complexes
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Categories: Homo sapiens | Large Structures | Ammirati M | Cygler M | Danley DE | Griffor MC | Kamath AV | Laird ER | Menard R | Pauly TA | Rath VL | Seddon AP | Sivaraman J | Sulea T | Wang IK
