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1p33

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Current revision (09:36, 16 August 2023) (edit) (undo)
 
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<StructureSection load='1p33' size='340' side='right'caption='[[1p33]], [[Resolution|resolution]] 2.86&Aring;' scene=''>
<StructureSection load='1p33' size='340' side='right'caption='[[1p33]], [[Resolution|resolution]] 2.86&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1p33]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Leita Leita]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P33 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1P33 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1p33]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Leishmania_tarentolae Leishmania tarentolae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P33 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1P33 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MTX:METHOTREXATE'>MTX</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.86&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1e7w|1e7w]], [[1e92|1e92]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MTX:METHOTREXATE'>MTX</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PTR1 OR LTDH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5689 LEITA])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1p33 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p33 OCA], [https://pdbe.org/1p33 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1p33 RCSB], [https://www.ebi.ac.uk/pdbsum/1p33 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1p33 ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pteridine_reductase Pteridine reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.33 1.5.1.33] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1p33 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p33 OCA], [http://pdbe.org/1p33 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1p33 RCSB], [http://www.ebi.ac.uk/pdbsum/1p33 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1p33 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PTR1_LEITA PTR1_LEITA]] Exhibits a NADPH-dependent biopterin reductase activity. Has good activity with folate and significant activity with dihydrofolate and dihydrobiopterin, but not with quinonoid dihydrobiopterin. Confers resistance to methotrexate (MTX).
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[https://www.uniprot.org/uniprot/PTR1_LEITA PTR1_LEITA] Exhibits a NADPH-dependent biopterin reductase activity. Has good activity with folate and significant activity with dihydrofolate and dihydrobiopterin, but not with quinonoid dihydrobiopterin. Confers resistance to methotrexate (MTX).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Leita]]
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[[Category: Leishmania tarentolae]]
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[[Category: Pteridine reductase]]
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[[Category: Bray T]]
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[[Category: Bray, T]]
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[[Category: Ferre RA]]
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[[Category: Ferre, R A]]
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[[Category: Matthews D]]
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[[Category: Matthews, D]]
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[[Category: Ouellette M]]
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[[Category: Ouellette, M]]
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[[Category: Varughese KI]]
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[[Category: Varughese, K I]]
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[[Category: Whiteley JM]]
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[[Category: Whiteley, J M]]
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[[Category: Zhao H]]
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[[Category: Zhao, H]]
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[[Category: Zhao M]]
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[[Category: Zhao, M]]
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[[Category: Complex]]
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[[Category: Mtx]]
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[[Category: Nadph]]
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[[Category: Oxidoreductase]]
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Current revision

Pteridine reductase from Leishmania tarentolae complex with NADPH and MTX

PDB ID 1p33

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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