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1p72

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==Crystal structure of EHV4-TK complexed with Thy and ADP==
==Crystal structure of EHV4-TK complexed with Thy and ADP==
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<StructureSection load='1p72' size='340' side='right' caption='[[1p72]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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<StructureSection load='1p72' size='340' side='right'caption='[[1p72]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1p72]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Ehv-4 Ehv-4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P72 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1P72 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1p72]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Equid_alphaherpesvirus_4 Equid alphaherpesvirus 4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P72 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1P72 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=THM:THYMIDINE'>THM</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1p6x|1p6x]], [[1p73|1p73]], [[1p75|1p75]], [[1p7c|1p7c]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=THM:THYMIDINE'>THM</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10331 EHV-4])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1p72 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p72 OCA], [https://pdbe.org/1p72 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1p72 RCSB], [https://www.ebi.ac.uk/pdbsum/1p72 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1p72 ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thymidine_kinase Thymidine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.21 2.7.1.21] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1p72 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p72 OCA], [http://pdbe.org/1p72 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1p72 RCSB], [http://www.ebi.ac.uk/pdbsum/1p72 PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/KITH_EHV4 KITH_EHV4]] In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome (By similarity).
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[https://www.uniprot.org/uniprot/KITH_EHV4 KITH_EHV4] In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p7/1p72_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p7/1p72_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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==See Also==
==See Also==
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*[[Thymidine kinase|Thymidine kinase]]
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*[[Thymidine kinase 3D structures|Thymidine kinase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Ehv-4]]
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[[Category: Equid alphaherpesvirus 4]]
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[[Category: Thymidine kinase]]
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[[Category: Large Structures]]
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[[Category: Gardberg, A]]
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[[Category: Gardberg A]]
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[[Category: Konrad, M]]
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[[Category: Konrad M]]
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[[Category: Lavie, A]]
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[[Category: Lavie A]]
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[[Category: Monnerjahn, C]]
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[[Category: Monnerjahn C]]
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[[Category: Shuvalova, L]]
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[[Category: Shuvalova L]]
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[[Category: Lid]]
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[[Category: P-loop]]
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[[Category: Transferase]]
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Current revision

Crystal structure of EHV4-TK complexed with Thy and ADP

PDB ID 1p72

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