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1pl9

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==Crystal structure of KDO8P synthase in its binary complex with substrate analog Z-FPEP==
==Crystal structure of KDO8P synthase in its binary complex with substrate analog Z-FPEP==
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<StructureSection load='1pl9' size='340' side='right' caption='[[1pl9]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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<StructureSection load='1pl9' size='340' side='right'caption='[[1pl9]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1pl9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PL9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1PL9 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1pl9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PL9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PL9 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FPE:3-FLUORO-2-(PHOSPHONOOXY)PROPANOIC+ACID'>FPE</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1g7u|1g7u]], [[1d9e|1d9e]], [[1phq|1phq]], [[1phw|1phw]], [[1q3n|1q3n]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FPE:3-FLUORO-2-(PHOSPHONOOXY)PROPANOIC+ACID'>FPE</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">KDSA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pl9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pl9 OCA], [https://pdbe.org/1pl9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pl9 RCSB], [https://www.ebi.ac.uk/pdbsum/1pl9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pl9 ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3-deoxy-8-phosphooctulonate_synthase 3-deoxy-8-phosphooctulonate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.55 2.5.1.55] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pl9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pl9 OCA], [http://pdbe.org/1pl9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1pl9 RCSB], [http://www.ebi.ac.uk/pdbsum/1pl9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1pl9 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/KDSA_ECOLI KDSA_ECOLI]] Synthesis of KDO 8-P which is required for lipid A maturation and cellular growth.[HAMAP-Rule:MF_00056]
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[https://www.uniprot.org/uniprot/KDSA_ECOLI KDSA_ECOLI] Synthesis of KDO 8-P which is required for lipid A maturation and cellular growth.[HAMAP-Rule:MF_00056]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1pl9 ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1pl9 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
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==See Also==
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*[[Kdo-8-phosphate synthase|Kdo-8-phosphate synthase]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bacillus coli migula 1895]]
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[[Category: Escherichia coli]]
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[[Category: 3-deoxy-8-phosphooctulonate synthase]]
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[[Category: Large Structures]]
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[[Category: Adir, N]]
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[[Category: Adir N]]
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[[Category: Baasov, T]]
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[[Category: Baasov T]]
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[[Category: Belakhov, V]]
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[[Category: Belakhov V]]
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[[Category: Rabkin, E]]
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[[Category: Rabkin E]]
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[[Category: Vainer, R]]
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[[Category: Vainer R]]
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[[Category: Beta-alpha-barrel]]
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[[Category: Flourinated analog]]
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[[Category: Lipopolysaccharide]]
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[[Category: Lyase]]
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[[Category: Transferase]]
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Current revision

Crystal structure of KDO8P synthase in its binary complex with substrate analog Z-FPEP

PDB ID 1pl9

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