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4nc3

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==Crystal structure of the 5-HT2B receptor solved using serial femtosecond crystallography in lipidic cubic phase.==
==Crystal structure of the 5-HT2B receptor solved using serial femtosecond crystallography in lipidic cubic phase.==
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<StructureSection load='4nc3' size='340' side='right' caption='[[4nc3]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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<StructureSection load='4nc3' size='340' side='right'caption='[[4nc3]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4nc3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NC3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NC3 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4nc3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NC3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NC3 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=DGA:DIACYL+GLYCEROL'>DGA</scene>, <scene name='pdbligand=ERM:ERGOTAMINE'>ERM</scene>, <scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene>, <scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ib4|4ib4]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=DGA:DIACYL+GLYCEROL'>DGA</scene>, <scene name='pdbligand=ERM:ERGOTAMINE'>ERM</scene>, <scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene>, <scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HTR2B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nc3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nc3 OCA], [https://pdbe.org/4nc3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nc3 RCSB], [https://www.ebi.ac.uk/pdbsum/4nc3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nc3 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nc3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nc3 OCA], [http://pdbe.org/4nc3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4nc3 RCSB], [http://www.ebi.ac.uk/pdbsum/4nc3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4nc3 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/5HT2B_HUMAN 5HT2B_HUMAN]] This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Plays a role in the regulation of impulsive behavior.
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[https://www.uniprot.org/uniprot/C562_ECOLX C562_ECOLX] Electron-transport protein of unknown function.[https://www.uniprot.org/uniprot/5HT2B_HUMAN 5HT2B_HUMAN] This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Plays a role in the regulation of impulsive behavior.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[5-hydroxytryptamine receptor|5-hydroxytryptamine receptor]]
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*[[5-hydroxytryptamine receptor 3D structures|5-hydroxytryptamine receptor 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bacillus coli migula 1895]]
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[[Category: Escherichia coli]]
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[[Category: Barty, A]]
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[[Category: Homo sapiens]]
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[[Category: Basu, S]]
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[[Category: Large Structures]]
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[[Category: Beyerlein, K R]]
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[[Category: Barty A]]
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[[Category: Boutet, S]]
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[[Category: Basu S]]
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[[Category: Caffrey, M]]
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[[Category: Beyerlein KR]]
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[[Category: Chapman, H N]]
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[[Category: Boutet S]]
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[[Category: Cherezov, V]]
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[[Category: Caffrey M]]
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[[Category: Fromme, P]]
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[[Category: Chapman HN]]
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[[Category: Fromme, R]]
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[[Category: Cherezov V]]
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[[Category: GPCR, GPCR Network]]
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[[Category: Fromme P]]
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[[Category: Gati, C]]
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[[Category: Fromme R]]
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[[Category: Grotjohann, I]]
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[[Category: Gati C]]
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[[Category: Han, G W]]
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[[Category: Grotjohann I]]
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[[Category: James, D]]
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[[Category: Han GW]]
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[[Category: Katritch, V]]
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[[Category: James D]]
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[[Category: Kirian, R A]]
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[[Category: Katritch V]]
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[[Category: Koglin, J E]]
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[[Category: Kirian RA]]
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[[Category: Kupitz, C]]
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[[Category: Koglin JE]]
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[[Category: Li, D]]
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[[Category: Kupitz C]]
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[[Category: Liu, W]]
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[[Category: Li D]]
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[[Category: Messerschmidt, M]]
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[[Category: Liu W]]
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[[Category: Nelson, G]]
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[[Category: Messerschmidt M]]
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[[Category: Rendek, K N]]
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[[Category: Nelson G]]
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[[Category: Seibert, M M]]
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[[Category: Rendek KN]]
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[[Category: Shah, S T.A]]
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[[Category: Seibert MM]]
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[[Category: Spence, J C.H]]
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[[Category: Shah STA]]
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[[Category: Stevens, R C]]
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[[Category: Spence JCH]]
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[[Category: Wacker, D]]
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[[Category: Stevens RC]]
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[[Category: Wang, C]]
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[[Category: Wacker D]]
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[[Category: Wang, D]]
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[[Category: Wang C]]
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[[Category: Weierstall, U]]
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[[Category: Wang D]]
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[[Category: White, T A]]
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[[Category: Weierstall U]]
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[[Category: Williams, G J]]
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[[Category: White TA]]
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[[Category: Zatsepin, N A]]
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[[Category: Williams GJ]]
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[[Category: Electron transport]]
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[[Category: Zatsepin NA]]
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[[Category: Ergotamine]]
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[[Category: Free electron laser]]
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[[Category: Gpcr]]
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[[Category: Gpcr network]]
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[[Category: Human 5ht2b receptor]]
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[[Category: Lipidic cubic phase]]
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[[Category: Membrane]]
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[[Category: Membrane protein]]
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[[Category: Novel protein engineering]]
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[[Category: Psi-biology]]
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[[Category: Serial femtosecond crystallography]]
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[[Category: Signaling protein]]
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[[Category: Structural genomic]]
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Current revision

Crystal structure of the 5-HT2B receptor solved using serial femtosecond crystallography in lipidic cubic phase.

PDB ID 4nc3

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