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5w45

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==Crystal structure of APOBEC3H==
==Crystal structure of APOBEC3H==
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<StructureSection load='5w45' size='340' side='right' caption='[[5w45]], [[Resolution|resolution]] 2.49&Aring;' scene=''>
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<StructureSection load='5w45' size='340' side='right'caption='[[5w45]], [[Resolution|resolution]] 2.49&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5w45]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5W45 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5W45 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5w45]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5W45 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5W45 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.486&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5w45 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5w45 OCA], [http://pdbe.org/5w45 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5w45 RCSB], [http://www.ebi.ac.uk/pdbsum/5w45 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5w45 ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5w45 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5w45 OCA], [https://pdbe.org/5w45 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5w45 RCSB], [https://www.ebi.ac.uk/pdbsum/5w45 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5w45 ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ABC3H_HUMAN ABC3H_HUMAN] DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. The A3H-var/haplotype 2 exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Exhibits antiviral activity also against T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons.<ref>PMID:16571802</ref> <ref>PMID:16920826</ref> <ref>PMID:18299330</ref> <ref>PMID:18779051</ref> <ref>PMID:18827027</ref> <ref>PMID:20062055</ref> <ref>PMID:21835787</ref> <ref>PMID:22457529</ref> <ref>PMID:22915799</ref> <ref>PMID:23097438</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Arutiunian, V]]
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[[Category: Homo sapiens]]
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[[Category: Chen, X J]]
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[[Category: Large Structures]]
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[[Category: Ito, F]]
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[[Category: Arutiunian V]]
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[[Category: Li, S X]]
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[[Category: Chen XJ]]
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[[Category: Wolfe, A]]
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[[Category: Ito F]]
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[[Category: Xiao, X]]
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[[Category: Li SX]]
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[[Category: Yang, H J]]
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[[Category: Wolfe A]]
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[[Category: Zirkle, B]]
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[[Category: Xiao X]]
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[[Category: Dna binding protein]]
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[[Category: Yang HJ]]
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[[Category: Mutase]]
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[[Category: Zirkle B]]

Current revision

Crystal structure of APOBEC3H

PDB ID 5w45

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