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7vf6
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | The | + | ==The crystal structure of PurZ0== |
| - | + | <StructureSection load='7vf6' size='340' side='right'caption='[[7vf6]], [[Resolution|resolution]] 1.70Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[7vf6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Gordonia_phage_Archimedes Gordonia phage Archimedes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7VF6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7VF6 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.703Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7vf6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7vf6 OCA], [https://pdbe.org/7vf6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7vf6 RCSB], [https://www.ebi.ac.uk/pdbsum/7vf6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7vf6 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/A0A7L7SI10_9CAUD A0A7L7SI10_9CAUD] Involved in the synthesis of the atypical nucleotide dZTP (2-amino-2'-deoxyadenosine-5'-triphosphate). Catalyzes the condensation of aspartate with deoxyguanylate into dSMP (N6-succino-2-amino-2'-deoxyadenylate), which undergoes defumarylation and phosphorylation respectively by host PurB and guanylate/nucleoside diphosphate kinases to give dZTP. dZTP is integrated into the viral genome instead of adenine by the viral DNA polymerase. This Z-base probably completely replaces adenosine and forms a triple bond to the opposite T-base. The resulting non-standard viral DNA is called Z-genome. The chemically modified DNA is probably harder for the host bacteria to digest with nucleases or restriction enzymes.[HAMAP-Rule:MF_04166] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Gordonia phage Archimedes]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Tong Y]] | ||
| + | [[Category: Zhang Y]] | ||
Current revision
The crystal structure of PurZ0
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