This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1v4q

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (10:29, 16 August 2023) (edit) (undo)
 
(10 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1v4q.gif|left|200px]]
 
-
{{Structure
+
==Three-dimensional solution structure of the analogue peptide of omega-conotoxin MVIIC==
-
|PDB= 1v4q |SIZE=350|CAPTION= <scene name='initialview01'>1v4q</scene>
+
<StructureSection load='1v4q' size='340' side='right'caption='[[1v4q]]' scene=''>
-
|SITE=
+
== Structural highlights ==
-
|LIGAND= <scene name='pdbligand=NH2:AMINO GROUP'>NH2</scene>
+
<table><tr><td colspan='2'>[[1v4q]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Conus_magus Conus magus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V4Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1V4Q FirstGlance]. <br>
-
|ACTIVITY=
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-
|GENE=
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
-
}}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1v4q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v4q OCA], [https://pdbe.org/1v4q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1v4q RCSB], [https://www.ebi.ac.uk/pdbsum/1v4q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1v4q ProSAT]</span></td></tr>
-
 
+
</table>
-
'''Three-dimensional solution structure of the analogue peptide of omega-conotoxin MVIIC'''
+
== Function ==
-
 
+
[https://www.uniprot.org/uniprot/O17C_CONMA O17C_CONMA] Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels (Cav). This toxin preferentially blocks P/Q-type calcium channels (Cav2.1/CACNA1A) (IC(50)=0.60 nM) (PubMed:1352986, PubMed:10938268). Shows also an inhibition on Cav2.2/CACNA1A channels (IC(50)=7.0 nM) (PubMed:10938268).<ref>PMID:10938268</ref> <ref>PMID:1352986</ref>
-
 
+
== References ==
-
==About this Structure==
+
<references/>
-
1V4Q is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V4Q OCA].
+
__TOC__
-
[[Category: Single protein]]
+
</StructureSection>
-
[[Category: Kobayashi, K.]]
+
[[Category: Conus magus]]
-
[[Category: Kohno, T.]]
+
[[Category: Large Structures]]
-
[[Category: Sasaki, T.]]
+
[[Category: Kobayashi K]]
-
[[Category: Sato, K.]]
+
[[Category: Kohno T]]
-
[[Category: NH2]]
+
[[Category: Sasaki T]]
-
[[Category: calcium channel blocker]]
+
[[Category: Sato K]]
-
[[Category: cystine knot motif]]
+
-
[[Category: omega-conotoxin]]
+
-
[[Category: triple-stranded antiparallel beta-sheet]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:40:45 2008''
+

Current revision

Three-dimensional solution structure of the analogue peptide of omega-conotoxin MVIIC

PDB ID 1v4q

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1v4q"
Personal tools