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1v4q
From Proteopedia
(Difference between revisions)
(New page: 200px<br /><applet load="1v4q" size="450" color="white" frame="true" align="right" spinBox="true" caption="1v4q" /> '''Three-dimensional solution structure of the ...) |
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| - | [[Image:1v4q.gif|left|200px]]<br /><applet load="1v4q" size="450" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="1v4q" /> | ||
| - | '''Three-dimensional solution structure of the analogue peptide of omega-conotoxin MVIIC'''<br /> | ||
| - | == | + | ==Three-dimensional solution structure of the analogue peptide of omega-conotoxin MVIIC== |
| - | + | <StructureSection load='1v4q' size='340' side='right'caption='[[1v4q]]' scene=''> | |
| - | [[ | + | == Structural highlights == |
| - | [[ | + | <table><tr><td colspan='2'>[[1v4q]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Conus_magus Conus magus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V4Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1V4Q FirstGlance]. <br> |
| - | [[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr> | |
| - | [ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1v4q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v4q OCA], [https://pdbe.org/1v4q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1v4q RCSB], [https://www.ebi.ac.uk/pdbsum/1v4q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1v4q ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Function == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/O17C_CONMA O17C_CONMA] Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels (Cav). This toxin preferentially blocks P/Q-type calcium channels (Cav2.1/CACNA1A) (IC(50)=0.60 nM) (PubMed:1352986, PubMed:10938268). Shows also an inhibition on Cav2.2/CACNA1A channels (IC(50)=7.0 nM) (PubMed:10938268).<ref>PMID:10938268</ref> <ref>PMID:1352986</ref> |
| - | [[Category: | + | == References == |
| - | [[Category: | + | <references/> |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| + | [[Category: Conus magus]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Kobayashi K]] | ||
| + | [[Category: Kohno T]] | ||
| + | [[Category: Sasaki T]] | ||
| + | [[Category: Sato K]] | ||
Current revision
Three-dimensional solution structure of the analogue peptide of omega-conotoxin MVIIC
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