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3fe3
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 3fe3 is ON HOLD Authors: Nugoor, C., Marx, A., Panneerselvam, S., Mandelkow, E.-M., Mandelkow, E. Description: Crystal structure of the kinase MARK...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the kinase MARK3/Par-1: T211A-S215A double mutant== | |
| + | <StructureSection load='3fe3' size='340' side='right'caption='[[3fe3]], [[Resolution|resolution]] 1.90Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3fe3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FE3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FE3 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fe3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fe3 OCA], [https://pdbe.org/3fe3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fe3 RCSB], [https://www.ebi.ac.uk/pdbsum/3fe3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fe3 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/MARK3_HUMAN MARK3_HUMAN] Involved in the specific phosphorylation of microtubule-associated proteins for tau, MAP2 and MAP4. Phosphorylates CDC25C on 'Ser-216'. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus.<ref>PMID:16980613</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Serine/threonine protein kinase 3D structures|Serine/threonine protein kinase 3D structures]] | |
| - | + | == References == | |
| - | + | <references/> | |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mandelkow E]] | ||
| + | [[Category: Mandelkow E-M]] | ||
| + | [[Category: Marx A]] | ||
| + | [[Category: Nugoor C]] | ||
| + | [[Category: Panneerselvam S]] | ||
Current revision
Crystal structure of the kinase MARK3/Par-1: T211A-S215A double mutant
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