This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
5hl1
From Proteopedia
(Difference between revisions)
| Line 3: | Line 3: | ||
<StructureSection load='5hl1' size='340' side='right'caption='[[5hl1]], [[Resolution|resolution]] 2.40Å' scene=''> | <StructureSection load='5hl1' size='340' side='right'caption='[[5hl1]], [[Resolution|resolution]] 2.40Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5hl1]] is a 4 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[5hl1]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HL1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5HL1 FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=63J:2-(PYRIDIN-2-YL)-N-(5-{4-[6-({[3-(TRIFLUOROMETHOXY)PHENYL]ACETYL}AMINO)PYRIDAZIN-3-YL]BUTYL}-1,3,4-THIADIAZOL-2-YL)ACETAMIDE'>63J</scene | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=63J:2-(PYRIDIN-2-YL)-N-(5-{4-[6-({[3-(TRIFLUOROMETHOXY)PHENYL]ACETYL}AMINO)PYRIDAZIN-3-YL]BUTYL}-1,3,4-THIADIAZOL-2-YL)ACETAMIDE'>63J</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5hl1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hl1 OCA], [https://pdbe.org/5hl1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5hl1 RCSB], [https://www.ebi.ac.uk/pdbsum/5hl1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5hl1 ProSAT]</span></td></tr> | |
| - | + | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/GLSK_HUMAN GLSK_HUMAN] Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate in the brain. Isoform 2 lacks catalytic activity. |
==See Also== | ==See Also== | ||
| Line 17: | Line 15: | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | + | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Cerione | + | [[Category: Cerione RA]] |
| - | [[Category: Huang | + | [[Category: Huang Q]] |
| - | + | ||
| - | + | ||
Current revision
Crystal structure of glutaminase C in complex with inhibitor CB-839
| |||||||||||
